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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 14 amino acid peptide from N-terminal extracellular domain of human GPRC6A.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
In IHC applications, antigen retrieval using Proteinase K treatment is recommended.
Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Rat, Hamster, Rabbit (93%) Monkey, Marmoset, Mouse, Dog, Elephant, Panda, Horse (86%).
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G11 and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BA86F4.3; G protein-coupled receptor, class C, group 6, member A; G protein-coupled receptor, family C, group 6, member A; G-protein coupled receptor GPCR33; GPRC6A; HGPCR33; HGPRC6A; Predicted with SOSUI analysis; seven transmembrane helix receptor
bA86F4.3; GPCR; GPRC6A