PA5-30953 targets GPS2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30953 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 253 of Human GPS2.
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This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.
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Protein Aliases: AMF-1; G protein pathway suppressor 2; GPS-2
Gene Aliases: AMF-1; GPS2
UniProt ID: (Human) Q13227
Entrez Gene ID: (Human) 2874