PA5-30593 targets GPX1 in IF, IHC (P), and WB applications and shows reactivity with Human, Mouse, and Rat samples.
The PA5-30593 immunogen is synthetic peptide corresponding to a region within amino acids 127 and 203 of Human GPX1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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Protein Aliases: Cellular glutathione peroxidase; Glutathione peroxidase 1; GPx-1; GPXD; GSHPx-1; GSHPX1; Selenium-dependent glutathione peroxidase 1
Gene Aliases: AI195024; AL033363; CGPx; Gpx; GPx-1; GPX1; GPXD; GSHPx; GSHPx-1; GSHPX1