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Invitrogen
GPX3 Polyclonal Antibody
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FIGURE: 1 / 3
GPX3 Antibody (PA5-22969) in ICC/IF
Immunocytochemistry analysis of GPX3 in HeLa cells. Samples were incubated with GPX3 polyclonal antibody (Product # PA5-22969) using a dilution of 1:250 followed by Dylight 488 (Green). Alpha-tubulin and nuclei were counterstained against Dylight 550 (Red) and DAPI blue).
Product Details
PA5-22969
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human Glutathione Peroxidase 3 expressed in E. coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The target sequence has 89% sequence homology with mouse, 88% sequence homology with bovine and 84% sequence homology with porcine.
Suggested positive control: HeLa whole cell extract.
Target Information
Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site (4-5).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Extracellular glutathione peroxidase; Glutathione peroxidase 3; glutathione peroxidase 3 (plasma); GPx-3; GPx-P; Plasma glutathione peroxidase; selenoprotein GPX3
Gene Aliases: GPx-3; GPx-P; GPX3; GPXP; GSHPx-3; GSHPx-P
UniProt ID: (Human) P22352, (Rat) P23764
Entrez Gene ID: (Human) 2878, (Rat) 64317
response to oxidative stress
response to lipid hydroperoxide
hydrogen peroxide catabolic process
cellular oxidant detoxification
response to molecule of fungal origin
glutathione metabolic process
female pregnancy
response to organic substance
response to selenium ion
response to organic cyclic compound
response to drug
protein homotetramerization
response to corticosterone
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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