Proteintech

GPX7 Polyclonal Antibody

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GPX7 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 13501-1-AP (GPX7 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

GPX7 Antibody in Western Blot (WB) — Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 13501-1-AP (GPX7 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

13501-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 6 publications 6 publications
Immunohistochemistry (IHC)	-	View 2 publications 2 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-

Product Specifications
Species Reactivity	Human
Published species	Chicken, Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	GPX7 Fusion Protein Ag4328 (58-187 aa encoded by BC032788) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.31 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: GFTDQHYRA LQQLQRDLGP HHFNVLAFPC NQFGQQEPDS NKEIESFARR TYSVSFPMFS KIAVTGTGAH PAFKYLAQTS GKEPTWNFWK YLVAPDGKVV GAWDPTVSVE EVRPQITALV RKLILLKRED L (58-187 aa encoded by BC032788)

Target Information

Human GPX 7 is believed to be a member of the glutathione peroxidase family of proteins. These proteins play important roles in cellular defense mechanisms against oxidative damage. This is accomplished by catalyzing the reduction of hydroperoxides and hydrogen peroxide through the reducing substrate, glutathione.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The development of antioxidant system in the intestinal tract of broiler chickens.

Poultry science

Tang D,Wu J,Jiao H,Wang X,Zhao J,Lin H

Fri Feb 01 00:00:00 EST 2019

Abrogation of glutathione peroxidase-1 drives EMT and chemoresistance in pancreatic cancer by activating ROS-mediated Akt/GSK3β/Snail signaling.

Oncogene

Meng Q,Shi S,Liang C,Liang D,Hua J,Zhang B,Xu J,Yu X

Thu Nov 01 00:00:00 EDT 2018

Loss of glutathione peroxidase 7 promotes TNF-α-induced NF-κB activation in Barrett's carcinogenesis.

Carcinogenesis

Peng DF,Hu TL,Soutto M,Belkhiri A,El-Rifai W

Tue Jul 01 00:00:00 EDT 2014

Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis.

Journal of Cancer

Peng DF,Hu TL,Soutto M,Belkhiri A,El-Rifai W

Wed Jun 25 00:00:00 EDT 2014

GPx8 peroxidase prevents leakage of H2O2 from the endoplasmic reticulum.

Free radical biology & medicine

Ramming T,Hansen HG,Nagata K,Ellgaard L,Appenzeller-Herzog C

Thu May 01 00:00:00 EDT 2014

Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma.

Gut

Peng D,Hu T,Soutto M,Belkhiri A,Zaika A,El-Rifai W

Tue Apr 01 00:00:00 EDT 2014

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.

EMBO molecular medicine

Chang YC,Yu YH,Shew JY,Lee WJ,Hwang JJ,Chen YH,Chen YR,Wei PC,Chuang LM,Lee WH

Thu Aug 01 00:00:00 EDT 2013

Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells.

Gut

Peng D,Belkhiri A,Hu T,Chaturvedi R,Asim M,Wilson KT,Zaika A,El-Rifai W

Sat Sep 01 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: CL683; FLJ14777; glutathione peroxidase 6; Glutathione peroxidase 7; GPx-7; HGNC:4559; non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase

Gene Aliases: CL683; GPx-7; GPX6; GPX7; GSHPx-7; NPGPx; UNQ469/PRO828

UniProt ID: (Human) Q96SL4

Entrez Gene ID: (Human) 2882

Molecular Function: peroxidase