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Bethyl Laboratories
GR Polyclonal Antibody
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Product Details
A303-491A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 150 and 200 of human Glucocorticoid Receptor.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Sheep
Target Information
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Glucocorticoid Receptor is expressed in the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. Studies have shown that glucocorticoid receptor (GR) must be associated with a complex of chaperone proteins for ligand activation. GR binds to known steroids such as dexamethasone with nanomolar affinity
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glucocorticoid receptor; GR; gr alpha; GR Kit; hGR DL-1; hGR NS-1; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3 group C member 1 variant hGR-B(54); nuclear receptor subfamily 3 group C member 1 variant hGR-B(77); nuclear receptor subfamily 3 group C member 1 variant hGR-B(93); nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); OTTHUMP00000222854; OTTHUMP00000222858; putative upstream ORF.; Unknown; unnamed protein product
Gene Aliases: GCCR; GCR; GCRST; GR; GRL; NR3C1
UniProt ID: (Human) P04150
Entrez Gene ID: (Human) 2908
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
glucocorticoid receptor activity
steroid binding
protein binding
zinc ion binding
lipid binding
TBP-class protein binding
protein kinase binding
estrogen response element binding
identical protein binding
sequence-specific DNA binding
metal ion binding
Hsp90 protein binding
steroid hormone binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
regulation of gluconeogenesis
chromatin organization
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
chromosome segregation
signal transduction
glucocorticoid metabolic process
response to wounding
gene expression
microglia differentiation
adrenal gland development
intracellular steroid hormone receptor signaling pathway
regulation of glucocorticoid biosynthetic process
nuclear receptor-mediated corticosteroid signaling pathway
synaptic transmission, glutamatergic
maternal behavior
glucocorticoid receptor signaling pathway
positive regulation of neuron apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
astrocyte differentiation
cell division
response to glucocorticoid
response to cortisol
mammary gland duct morphogenesis
motor behavior
cellular response to steroid hormone stimulus
cellular response to glucocorticoid stimulus
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
neuroinflammatory response
response to ketone
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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