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Proteintech
GRAF Polyclonal Antibody
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Product Details
17747-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GRAF Fusion Protein Ag12008 (403-759 aa encoded by BC068555)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RGINEQGLY RIVGVNSRVQ KLLSVLMDPK TASETETDIC AEWEIKTITS ALKTYLRMLP GPLMMYQFQR SFIKAAKLEN QESRVSEIHS LVHRLPEKNR QMLQLLMNHL ANVANNHKQN LMTVANLGVV FGPTLLRPQE ETVAAIMDIK FQNIVIEILI ENHEKIFNTV PDMPLTNAQL HLSRKKSSDS KPPSCSERPL TLFHTVQSTE KQEQRNSIIN SSLESVSSNP NSILNSSSSL QPNMNSSDPD LAVVKPTRPN SLPPNPSPTS PLSPSWPMFS APSSPMPTSS TSSDSSPVST PFRKAKALYA CKAEHDSELS FTAGTVFDNV HPSQEPGWLE GTLNGKTGLI PENYVEFL (403-759 aa encoded by BC068555)
Target Information
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ42530; GRAF1; GTPase regulator associated with focal adhesion kinase; GTPase regulator associated with focal adhesion kinase pp125(FAK); Oligophrenin-1-like protein; Rho GTPase-activating protein 26; Rho-type GTPase-activating protein 26
Gene Aliases: 1810044B20Rik; 2610010G17Rik; 4933432P15Rik; AI853435; ARHGAP26; GRAF; GRAF1; KIAA0621; mKIAA0621; OPHN1L; OPHN1L1
UniProt ID: (Human) Q9UNA1, (Mouse) Q6ZQ82
Entrez Gene ID: (Human) 23092, (Mouse) 71302
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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