PA5-30404 targets GRAP in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-30404 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 202 of Human GRAP.
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This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.
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Protein Aliases: GRB2-related adapter protein; growth factor receptor-bound protein 2-related adaptor protein
Gene Aliases: 8430435N19Rik; BB233594; GRAP