Immunogen sequence: LNELVDFYRT TTIAKKRQIF MYLTGLCFLL GPTQLTQRLP VSRQECPRQE QDIVFLIDGS GSISSRNFAT MMNFVRAVIS QFQRPSTQFS LMQFSNKFQT HFTFEEFRRS SNPLSLLASV HQLQGFTYTA TAIQNVVHRL FHASYGARRD AAKILIVITD GKKEGDSLDY KDVIPMADAA GIIRYAIGVG LAFQNRNSWK ELNDIASKPS QEHIFKVEDF DALKDIQNQL KEKIFAIEGT ETTSSSSFEL E; Positive Samples: U-251MG, A-549
This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.
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Protein Aliases: GRB2-related adapter protein; growth factor receptor-bound protein 2-related adaptor protein
Gene Aliases: GRAP
UniProt ID: (Human) Q13588
Entrez Gene ID: (Human) 10750