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Invitrogen
GRAP Polyclonal Antibody
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FIGURE: 1 / 1
GRAP Antibody (PA5-90434) in WB
Western blot analysis of GRAP in extracts of various cell lines. Samples were incubated with GRAP Polyclonal antibody (Product # PA5-90434) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-90434
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 128-217 of human GRAP (NP_0066041)
Conjugate
Form
Liquid
Concentration
1.48 mg/mL
Amount
148 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LNELVDFYRT TTIAKKRQIF LRDEEPLLKS PGACFAQAQF DFSAQDPSQL SFRRGDIIEV LERPDPHWWR GRSCGRVGFF PRSYVQPVHL; Positive Samples: U-251MG, A-549
Target Information
This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GRAP; GRB2-related adapter protein; growth factor receptor-bound protein 2-related adaptor protein; MGC64880
Gene Aliases: DFNB114; GRAP
UniProt ID: (Human) Q13588
Entrez Gene ID: (Human) 10750
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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