Search
Proteintech
GRB10 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
23591-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GRB10 Fusion Protein Ag20355 (1-80 aa encoded by BC024285)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MNASLESLY SACSMQSDTV PLLQNGQHAR SQPRASGPPR SIQPQVSPRQ RVQRSQPVHI LAVRRLQEED QQFRTSSLPA I (1-80 aa encoded by BC024285)
Target Information
GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Grb-IRgamma/hGrb10gamma; GRB10 adapter protein; GRB10 adaptor protein; Growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; KIAA0207; maternally expressed gene 1; Maternally expressed gene 1 protein; OTTHUMP00000197988; OTTHUMP00000197989; OTTHUMP00000197990; OTTHUMP00000197991; OTTHUMP00000197993; OTTHUMP00000197994; SH2 domain; SH2 domain containing protein; splice variant of Grb10; unnamed protein product
Gene Aliases: 5730571D09Rik; AI325020; Grb-10; GRB-IR; GRB10; GRBIR; IRBP; KIAA0207; MEG1; mKIAA0207; RGD1566234; RSS
UniProt ID: (Human) Q13322, (Mouse) Q60760, (Rat) P0CE43
Entrez Gene ID: (Human) 2887, (Mouse) 14783, (Rat) 498416
signal transduction
insulin receptor signaling pathway
gene expression
negative regulation of Wnt signaling pathway
positive regulation of vascular endothelial growth factor receptor signaling pathway
response to insulin
positive regulation of phosphorylation
negative regulation of glycogen biosynthetic process
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
insulin-like growth factor receptor signaling pathway
ERK1 and ERK2 cascade
positive regulation of cold-induced thermogenesis
vascular associated smooth muscle cell migration
positive regulation of signal transduction
negative regulation of phosphorylation
biological_process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support