|Immunohistochemistry (Paraffin) (IHC (P))||0.1-0.3 ug/ml|
|Western Blot (WB)||0.05-0.15 µg/ml|
|Tested Species reactivity||Human, Mouse, Pig, Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to the C terminus amino acids PRNYVTPVNRNV.|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is expected to recognize both reported isoforms (NP_002077.1 and NP_987102.1).
This antibody is predicted to react with bovine and canine based on sequence homology.
GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2 - Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signalling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: abundant SRC homology; Adapter protein GRB2; ASH protein; EGFRBP-GRB2; epidermal growth factor; epidermal growth factor receptor-binding protein GRB2; Grb3-3; growth factor receptor bound protein 2; Growth Factor Receptor-bound protein 2; growth factor receptor-bound protein 3; HT027; MST084; MSTP084; Protein Ash; SH2/SH3 adapter GRB2
Gene Aliases: AA408164; ASH; EGFRBP-GRB2; GRB2; Grb3-3; MST084; MSTP084; NCKAP2
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