This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
This antibody is expected to recognize both reported isoforms (NP_002077.1 and NP_987102.1).
This antibody is predicted to react with bovine and canine based on sequence homology.
GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2 - Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signalling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: abundant SRC homology; Adapter protein GRB2; ASH protein; EGFRBP-GRB2; epidermal growth factor; epidermal growth factor receptor-binding protein GRB2; Grb3-3; growth factor receptor bound protein 2; Growth Factor Receptor-bound protein 2; growth factor receptor-bound protein 3; HT027; MST084; MSTP084; Protein Ash; SH2/SH3 adapter GRB2
Gene Aliases: AA408164; ASH; EGFRBP-GRB2; GRB2; Grb3-3; MST084; MSTP084; NCKAP2