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|Tested species reactivity||Human, Mouse, Pig, Rat|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to the C terminus amino acids PRNYVTPVNRNV.|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||0.1-0.3 ug/ml|
|Western Blot (WB)||0.05-0.15 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is expected to recognize both reported isoforms (NP_002077.1 and NP_987102.1).
This antibody is predicted to react with bovine and canine based on sequence homology.
GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2 - Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signalling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
abundant SRC homology; adapter protein GRB2; ASH protein; EGFRBP-GRB2; epidermal growth factor; epidermal growth factor receptor-binding protein GRB2; Grb3-3; Growth Factor Receptor-bound protein 2; growth factor receptor-bound protein 3; HT027; MST084; MSTP084; protein Ash; SH2/SH3 adapter GRB2
AA408164; ASH; EGFRBP-GRB2; GRB2; Grb3-3; MST084; MSTP084; NCKAP2