This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-27151 targets GRB2 in WB applications and shows reactivity with Human and mouse samples.
The PA5-27151 immunogen is synthetic peptide corresponding to a region within amino acids 156 and 167 of Human GRB2.
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The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: abundant SRC homology; Adapter protein GRB2; EGFRBP-GRB2; epidermal growth factor receptor-binding protein GRB2; Grb3-3; Growth factor receptor-bound protein 2; growth factor receptor-bound protein 3; HT027; MST084; MSTP084; NCKAP2; Protein Ash; SH2/SH3 adapter GRB2
Gene Aliases: AA408164; ASH; EGFRBP-GRB2; GRB2; Grb3-3; MST084; MSTP084; NCKAP2