Suggested positive control: human colon cancer tissue.
In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cell proliferation-inducing gene 2 protein; colorectal adenoma and carcinoma 1; Cysteine knot superfamily 1, BMP antagonist 1; DAN domain family member 2; Down-regulated in Mos-transformed cells protein; gremlin 1, cysteine knot superfamily, homolog; gremlin 1-like protein; Gremlin-1; IHG-2; Increased in high glucose protein 2; increased in high glucose-2
Gene Aliases: C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREM1; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
UniProt ID: (Human) O60565
Entrez Gene ID: (Human) 26585