In direct ELISAs, approximately 40% cross-reactivity with recombinant mouse (rm) PRDC/Gremlin-2 is observed, approximately 10% cross-reactivity with recombinant human (rh) Gremlin is observed and less than 5% cross-reactivity with rmDan, rhCerberus-1, and recombinant chicken Caronte is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cysteine knot superfamily 1, BMP antagonist 1; Down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; Gremlin-1
Gene Aliases: Cktsf1b1; Drm; Grem; Grem1; ld
UniProt ID: (Mouse) O70326
Entrez Gene ID: (Mouse) 23892