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Product Details
PA5-70341
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of rat GREM1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2691293
Product Specific Information
This target displays homology in the following species: Cow: 92%; Dog: 100%; Goat: 92%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 92%; Rat: 100%; Zebrafish: 93%
Target Information
In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cysteine knot superfamily 1, BMP antagonist 1; Down-regulated in Mos-transformed cells protein; down-regulated in v-mos-transformed cells; gremlin 1 homolog, cysteine knot superfamily; Gremlin-1
Gene Aliases: Cktsf1b1; Drm; Grem; Grem1; ld
UniProt ID: (Rat) O35793, (Mouse) O70326
Entrez Gene ID: (Rat) 50566, (Mouse) 23892
cell morphogenesis
angiogenesis
branching involved in ureteric bud morphogenesis
cell migration involved in sprouting angiogenesis
positive regulation of receptor internalization
negative regulation of leukocyte chemotaxis
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
mesenchymal to epithelial transition involved in metanephros morphogenesis
apoptotic process
signal transduction
activation of transmembrane receptor protein tyrosine kinase activity
cell-cell signaling
positive regulation of cell proliferation
organ morphogenesis
proximal/distal pattern formation
regulation of epithelial to mesenchymal transition
collagen fibril organization
negative regulation of cell growth
embryonic limb morphogenesis
negative regulation of bone mineralization
negative regulation of BMP signaling pathway
negative regulation of chondrocyte differentiation
regulation of stress-activated MAPK cascade
negative regulation of osteoblast proliferation
positive regulation of NF-kappaB import into nucleus
negative regulation of apoptotic process
endothelial cell migration
positive regulation of angiogenesis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of bone remodeling
determination of dorsal identity
positive regulation of NF-kappaB transcription factor activity
regulation of focal adhesion assembly
positive regulation of telomerase activity
limb development
negative regulation of pathway-restricted SMAD protein phosphorylation
ureteric bud formation
positive regulation of protein tyrosine kinase activity
signal transduction by p53 class mediator
negative regulation of monocyte chemotaxis
negative regulation of canonical Wnt signaling pathway
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of branching involved in ureteric bud morphogenesis
negative regulation of osteoclast proliferation
positive regulation of peptidyl-tyrosine autophosphorylation
negative regulation of bone trabecula formation
negative regulation of bone mineralization involved in bone maturation
positive regulation of receptor activity
positive regulation of cardiac muscle cell differentiation
Performance Guarantee
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