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GREM2 Antibody (PA5-106413) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded GREM2 in human Melanoma tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with GREM2 polyclonal antibody (Product # PA5-106413) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-106413
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GREM2(Accession Q9H772), corresponding to amino acid residues L68-C87.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2854086
Target Information
GREM2 encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CKTSF1B2FLJ21195; Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; DAND3Prdc; gremlin 2, cysteine knot superfamily, homolog; Gremlin-2; Gremlin1; PRDC; PRDCgremlin 2; Protein related to DAN and cerberus
Gene Aliases: CKTSF1B2; DAND3; GREM2; Gremlin2; PRDC
UniProt ID: (Human) Q9H772, (Mouse) O88273
Entrez Gene ID: (Human) 64388, (Mouse) 23893
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