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Invitrogen
GRHL2 Polyclonal Antibody
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Product Details
PA5-52116
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GRHL2. Recombinant protein control fragment (Product #RP-102291).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NRVQVLKTVP VNLSLNQDHL ENSKREQYSI SFPESSAIIP VSGITVVKAE DFTPVFMAPP VHYPRGDGEE QRVVIFEQTQ YDVPSLATHS AYLKDDQRST PDSTYSESFK DAATEKFRSA SVGAEEYMYD QTSSGTFQYT LEATKSLRQK
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 87%.
Target Information
The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brother of mammalian grainyhead; brother-of-MGR; grainyhead-like 2; Grainyhead-like protein 2 homolog; Transcription factor CP2-like 3; unnamed protein product
Gene Aliases: BOM; DFNA28; ECTDS; GRHL2; PPCD4; TFCP2L3
UniProt ID: (Human) Q6ISB3
Entrez Gene ID: (Human) 79977
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
intronic transcription regulatory region sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
identical protein binding
sequence-specific DNA binding
DNA-binding transcription factor binding
in utero embryonic development
neural tube closure
cardiac ventricle morphogenesis
epithelial cell morphogenesis
regulation of transcription from RNA polymerase II promoter
cell adhesion
brain development
epidermis development
regulation of gene expression
neural tube development
keratinocyte differentiation
respiratory tube development
cell junction assembly
multicellular organism growth
embryonic digit morphogenesis
camera-type eye development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic organ development
embryonic cranial skeleton morphogenesis
face development
lung lobe morphogenesis
lung epithelial cell differentiation
epithelial cell morphogenesis involved in placental branching
anterior neural tube closure
bicellular tight junction assembly
epithelium migration
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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