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Fabgennix
GRIK1 Polyclonal Antibody, FITC
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Product Details
GLUR5-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to unique amino acid region on GluR5.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GluK1; GluR-5; glutamate receptor; Glutamate receptor 5; Glutamate receptor ionotropic, kainate 1; glutamate receptor subunit 5
Gene Aliases: A830007B11Rik; D16Ium24; D16Ium24e; GluK1; GluK5; Glur-5; GluR5; Glurbeta1; Grik1
UniProt ID: (Rat) P22756
Entrez Gene ID: (Rat) 29559, (Mouse) 14805
ionotropic glutamate receptor activity
extracellular-glutamate-gated ion channel activity
protein binding
drug binding
kainate selective glutamate receptor activity
glutamate binding
voltage-gated cation channel activity
protein homodimerization activity
receptor activity
ion channel activity
transmembrane signal receptor
chemical synaptic transmission
nervous system development
positive regulation of gamma-aminobutyric acid secretion
adult behavior
negative regulation of synaptic transmission, GABAergic
positive regulation of synaptic transmission, GABAergic
ion transmembrane transport
regulation of ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
regulation of synaptic plasticity
regulation of short-term neuronal synaptic plasticity
behavioral response to pain
membrane depolarization
negative regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
inhibitory postsynaptic potential
transport
ion transport
regulation of long-term neuronal synaptic plasticity
cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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