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Product Details
PA5-20447
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide near the carboxy terminus of the human Grik1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11155794
Product Specific Information
A suggested positive control is P815 cell lysate.
PA5-20447 can be used with blocking peptide PEP-0564.
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EAA3; Excitatory amino acid receptor 3; GluK1; GluR-5; glutamate receptor; Glutamate receptor 5; Glutamate receptor ionotropic, kainate 1; glutamate receptor subunit 5; glutamate receptor, ionotropic, kainate 1
Gene Aliases: A830007B11Rik; D16Ium24; D16Ium24e; EAA3; EEA3; GLR5; GluK1; GluK5; Glur-5; GLUR5; Glurbeta1; GRIK1
UniProt ID: (Human) P39086
Entrez Gene ID: (Human) 2897, (Mouse) 14805
extracellular-glutamate-gated ion channel activity
ligand-gated ion channel activity
kainate selective glutamate receptor activity
receptor activity
ionotropic glutamate receptor activity
ion channel activity
protein binding
drug binding
glutamate binding
voltage-gated cation channel activity
protein homodimerization activity
transmembrane signal receptor
transport
glutamate receptor signaling pathway
chemical synaptic transmission
nervous system development
central nervous system development
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
regulation of synaptic transmission, glutamatergic
ion transport
positive regulation of gamma-aminobutyric acid secretion
adult behavior
negative regulation of synaptic transmission, GABAergic
positive regulation of synaptic transmission, GABAergic
regulation of ion transmembrane transport
synaptic transmission, glutamatergic
regulation of membrane potential
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
behavioral response to pain
membrane depolarization
negative regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
inhibitory postsynaptic potential
cation transmembrane transport
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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