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Proteintech
GRIK2 Polyclonal Antibody
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Product Details
13597-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GRIK2 Fusion Protein Ag4516 (27-353 aa encoded by BC037954)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GYSQGTTHV LRFGGIFEYV ESGPMGAEEL AFRFAVNTIN RNRTLLPNTT LTYDTQKINL YDSFEASKKA CDQLSLGVAA IFGPSHSSSA NAVQSICNAL GVPHIQTRWK HQVSDNKDSF YVSLYPDFSS LSRAILDLVQ FFKWKTVTVV YDDSTGLIRL QELIKAPSRY NLRLKIRQLP ADTKDAKPLL KEMKRGKEFH VIFDCSHEMA AGILKQALAM GMMTEYYHYI FTTLDLFALD VEPYRYSGVN MTGFRILNTE NTQVSSIIEK WSMERLQAPP KPDSGLLDGF MTMEFHSCCP GWSAMARSHL TATSASWVQA ILLPQPPE (27-353 aa encoded by BC037954 )
Target Information
Glutamate receptors are the primary excitatory neurotransmitter receptors in the mammalian brain and are activated during various normal neurophysiological processes. The kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels, includes this gene product. The subunit encoded by this gene is edited at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Furthermore, different isoforms of this gene have been described due to alternatively spliced transcript variants. Mutations in this gene have been linked to autosomal recessive cognitive disability. GRIK2-associated diseases include Neurodevelopmental Disorder with Impaired Language and Ataxia and with or without Seizures and Intellectual Developmental Disorder, Autosomal Recessive 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bA487F5.1; EAA4; Excitatory amino acid receptor 4; GLR 6; GluK2; GLUR 6; gluR beta-2; GluR-6; glutamate receptor; Glutamate receptor 6; glutamate receptor beta-2; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; Glutamate receptor ionotropic, kainate 2; glutamate receptor, ionotropic kainate 2; glutamate receptor, ionotropic, kainate 2; GRIK 2; GRIK2 protein
Gene Aliases: AW124492; EAA4; GLR6; GluK2; GLUK6; Glur-6; GLUR6; Glurbeta2; GRIK2; MRT6
UniProt ID: (Human) D7RWZ4, (Rat) P42260
Entrez Gene ID: (Human) 2898, (Rat) 54257, (Mouse) 14806
extracellular-glutamate-gated ion channel activity
ligand-gated ion channel activity
kainate selective glutamate receptor activity
PDZ domain binding
ubiquitin conjugating enzyme binding
ubiquitin protein ligase binding
protein homodimerization activity
ionotropic glutamate receptor activity
protein binding
glutamate receptor activity
identical protein binding
receptor activity
ion channel activity
transmembrane signal receptor
behavioral fear response
transport
cellular calcium ion homeostasis
intracellular protein transport
glutamate receptor signaling pathway
chemical synaptic transmission
neuronal action potential
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
receptor clustering
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
regulation of JNK cascade
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
modulation of synaptic transmission
positive regulation of synaptic transmission
neuron apoptotic process
negative regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
inhibitory postsynaptic potential
signal transduction
regulation of membrane potential
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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