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GRIK2/GLR6 Polyclonal Antibody
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Product Details
BS-12006R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GRIK2/GLR6, amino acids 164-270.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Glutamate receptors are the primary excitatory neurotransmitter receptors in the mammalian brain and are activated during various normal neurophysiological processes. The kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels, includes this gene product. The subunit encoded by this gene is edited at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Furthermore, different isoforms of this gene have been described due to alternatively spliced transcript variants. Mutations in this gene have been linked to autosomal recessive cognitive disability. GRIK2-associated diseases include Neurodevelopmental Disorder with Impaired Language and Ataxia and with or without Seizures and Intellectual Developmental Disorder, Autosomal Recessive 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bA487F5.1; EAA4; Excitatory amino acid receptor 4; GLR 6; GluK2; GluK2(alt_5'UTR); GLUR 6; GluR beta-2; GluR-6; glutamate receptor; Glutamate receptor 6; Glutamate receptor beta-2; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; Glutamate receptor ionotropic, kainate 2; glutamate receptor, ionotropic kainate 2; GRIK 2; GRIK2 protein; kainate 2; putative NMDtranscript(cassette_171nt); unnamed protein product
Gene Aliases: AW124492; EAA4; GLR6; GluK2; GLUK6; Glur-6; GLUR6; Glurbeta2; GRIK2; MRT6; NEDLAS
UniProt ID: (Human) Q13002, (Rat) P42260, (Mouse) P39087
Entrez Gene ID: (Human) 2898, (Rat) 54257, (Mouse) 14806
SNARE binding
ionotropic glutamate receptor activity
ion channel activity
extracellular-glutamate-gated ion channel activity
glutamate receptor activity
ligand-gated ion channel activity
kainate selective glutamate receptor activity
glutamate-gated calcium ion channel activity
PDZ domain binding
ubiquitin conjugating enzyme binding
ubiquitin protein ligase binding
signaling receptor activity
identical protein binding
scaffold protein binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
protein binding
protein homodimerization activity
receptor activity
transmembrane signal receptor
behavioral fear response
ion transport
cellular calcium ion homeostasis
glutamate receptor signaling pathway
chemical synaptic transmission
neuronal action potential
calcium-mediated signaling
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
receptor clustering
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
regulation of JNK cascade
regulation of long-term neuronal synaptic plasticity
regulation of short-term neuronal synaptic plasticity
modulation of synaptic transmission
positive regulation of synaptic transmission
neuron apoptotic process
negative regulation of synaptic transmission, glutamatergic
excitatory postsynaptic potential
inhibitory postsynaptic potential
modulation of excitatory postsynaptic potential
presynaptic modulation of chemical synaptic transmission
regulation of presynaptic membrane potential
detection of cold stimulus involved in thermoception
intracellular protein transport
signal transduction
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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