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GRIK3/GLR7 Polyclonal Antibody
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FIGURE: 1 / 1
GRIK3/GLR7 Antibody (BS-12007R) in Flow
MCF7 cells were incubated in 5% BSA blocking buffer for 30 min at room temperature. Cells were then stained with GRIK3/GLR7 Antibody (bs-12007R) at 1:50 dilution in blocking buffer and incubated for 30 min at room temperature, washed twice with 2%BSA in PBS, followed by secondary antibody incubation for 40 min at room temperature. Acquisitions of 20,000 events were performed. Cells stained with primary antibody (green), and isotype control (orange).
Product Details
BS-12007R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GRIK3/GLR7, amino acids 501-600.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7)); EAA5; Excitatory amino acid receptor 5; GluK3; GluR-7; glutamate receptor; Glutamate receptor 7; Glutamate receptor ionotropic, kainate 3; glutamate receptor subunit kainate subtype
Gene Aliases: 9630027E11; EAA5; GLR7; GluK3; Glur-7; GLUR7; GluR7-3; GluR7a; GRIK3
UniProt ID: (Human) Q13003, (Rat) P42264, (Mouse) B1AS29
Entrez Gene ID: (Human) 2899, (Rat) 298521, (Mouse) 14807
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
ionotropic glutamate receptor activity
ion channel activity
glutamate receptor activity
ligand-gated ion channel activity
kainate selective glutamate receptor activity
glutamate-gated calcium ion channel activity
signaling receptor activity
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
extracellular-glutamate-gated ion channel activity
receptor activity
protein binding
transmembrane signal receptor
ion transport
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
calcium-mediated signaling
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
modulation of synaptic transmission
negative regulation of synaptic transmission, glutamatergic
regulation of postsynaptic membrane potential
regulation of presynaptic membrane potential
signal transduction
chemical synaptic transmission
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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