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GRIK5 Polyclonal Antibody
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FIGURE: 1 / 3
GRIK5 Antibody (OSG00064W-100UL) in IHC (P)
IHC on rat spinal cord (paraffin section) using Rabbit antibody to 1t extracellular domain of GRIK5 (EAA2, Glutamate receptor KA-2): whole serum (OSG00064W) at 1 : 200 dilution incubated overnight at 4C, developed with DAB/Ni and counterstained with hematoxylin.
Product Details
OSG00064W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from 1t extracellular domain of human GRIK5 (EAA2, Glutamate receptor KA-2) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: GRIK5.
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EAA2; Excitatory amino acid receptor 2; GluK5; GluR gamma-2; glutamate receptor; Glutamate receptor gamma-2; Glutamate receptor ionotropic, kainate 5; Glutamate receptor KA-2; glutamate receptor KA2; glutamate receptor, ionotropic kainate 5; KA2; kainate receptor subunit; putative NMDtranscript(altDon_e2); putative NMDtranscript(del_e13-e15)
Gene Aliases: EAA2; GluK5; GluRgamma2; GRIK2; GRIK5; iGlu5; KA2
UniProt ID: (Human) Q16478, (Rat) Q63273, (Mouse) Q61626
Entrez Gene ID: (Human) 2901, (Rat) 24407, (Mouse) 14809
ionotropic glutamate receptor activity
ion channel activity
ligand-gated ion channel activity
kainate selective glutamate receptor activity
signaling receptor activity
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
extracellular-glutamate-gated ion channel activity
protein binding
glutamate receptor activity
SH3 domain binding
PDZ domain binding
identical protein binding
receptor activity
transmembrane signal receptor
ion transport
glutamate receptor signaling pathway
regulation of synaptic vesicle fusion to presynaptic membrane
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
modulation of synaptic transmission
excitatory postsynaptic potential
regulation of presynaptic membrane potential
protein retention in ER lumen
signal transduction
chemical synaptic transmission
receptor clustering
positive regulation of neuron apoptotic process
establishment of localization in cell
cellular response to glucose stimulus
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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