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Proteintech
GRIP1 Polyclonal Antibody
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Product Details
22398-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GRIP1 Fusion Protein Ag18071 (702-964 aa encoded by BC115393)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Amount
79.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QTDAQSASS PKKFPISSHL SDLGDVEEDS SPAQKPGKLS DMYPSTVPSV DSAVDSWDGS AIDTSYGTEG TSFQASGYNF NTYDWRSPKQ RGSLSPVTKP RSQTYPDVGL SYEDWDRSTA SGFAGAADSA ETEQEENFWS QALEDLETCG QSGILRELEE KADRRVSLRN MTLLATIMSG STMSLNHEAP TPRSQLGRQA SFQERSSSRP HYSQTTRSNT LPSDVGRKSV TLRKMKQEIK EIMSPTPVEL HKVTLYKDSD MEDF (702-964 aa encoded by B C115393)
Target Information
Steroid and thyroid hormones and retinoic acid regulate a complex array of gene expression activity via intracellular receptor transcription factors belonging to the ligand-dependent nuclear receptor superfamily. Adding to the complexity of function of these transcription factors are associated proteins known as coactivators and corepressors which, as their names suggest, enhance or depress transcription activity of the nuclear receptor with which they associate. Glucocorticoid receptor interacting protein-1 (GRIP1), or Transcription Intermediary Factor 2 (TIF2), is a member of a family of transcriptional coactivator proteins which includes steroid receptor coactivator-1 (SRC-1) and Amplified in breast cancer-1 (AIB-1). GRIP1 has been shown to interact and stimulate transcriptional activity of the retinoic acid, retinoid X, vitamin D, mineralocorticoid, glucocorticoid, thyroid hormone, androgen, estrogen, progesterone, and peroxisome proliferator activated receptors. GRIP1 also contains several copies of the conserved LXXLL/LLXXL motif which has been demonstrated to be critical to receptor-coactivator interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AMPA receptor-interacting protein GRIP1; eye blebs; Glutamate receptor-interacting protein 1; GRIP-1; unnamed protein product
Gene Aliases: 4931400F03Rik; eb; FRASRS3; GRIP; GRIP1
UniProt ID: (Human) Q9Y3R0, (Rat) P97879, (Mouse) Q925T6
Entrez Gene ID: (Human) 23426, (Rat) 84016, (Mouse) 74053
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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