Positive Control: Jurkat, Raji, NCI-H929
Predicted Reactivity: Mouse (100%), Rat (100%), Pig (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
GRK2 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADRBK1; adrenergic; adrenergic beta receptor kinase 1; adrenergic, beta, receptor kinase 1; BARK1; beta; Beta-adrenergic receptor kinase 1; Beta-ARK-1; BETA-ARK1; G-protein coupled receptor kinase 2; receptor kinase 1
Gene Aliases: ADRBK1; BARK; BARK1; BETA-ARK1; GRK2
UniProt ID: (Human) P25098
Entrez Gene ID: (Human) 156