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Proteintech
GRK5 Polyclonal Antibody
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Product Details
17032-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GRK5 Fusion Protein Ag10511 (186-590 aa encoded by BC064506)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FRQYRVLGK GGFGEVCACQ VRATGKMYAC KRLEKKRIKK RKGESMALNE KQILEKVNSQ FVVNLAYAYE TKDALCLVLT IMNGGDLKFH IYNMGNPGFE EERALFYAAE ILCGLEDLHR ENTVYRDLKP ENILLDDYGH IRISDLGLAV KIPEGDLIRG RVGTVGYMAP EVLNNQRYGL SPDYWGLGCL IYEMIEGQSP FRGRKEKVKR EEVDRRVLET EEVYSHKFSE EAKSICKMLL TKDAKQRLGC QEEGAAEVKR HPFFRNMNFK RLEAGMLDPP FVPDPRAVYC KDVLDIEQFS TVKGVNLDHT DDDFYSKFST GSVSIPWQNE MIETECFKEL NVFGPNGTLP PDLNRNHPPE PPKKGLLQRL FKRQHQNNSK SSPSSKTSFN HHINSNHVSS NSTGSS (186-590 aa encoded by BC064506)
Target Information
GRK5 is a serine/threonine kinase that regulates the activity of a variety of G protein-coupled receptors and the motility of polymorphonuclear leukocytes. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha-CP4; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5; GRK; GRK-pan; Pan-GRK; Poly(rC)-binding protein 4; unnamed protein product
Gene Aliases: 1200003L19Rik; AlphaCP-4; FP2025; GPRK5; GRK5; Pcbp4
UniProt ID: (Human) P34947, (Mouse) Q8VEB1, (Rat) Q62833, (Mouse) P57724
Entrez Gene ID: (Human) 2869, (Mouse) 14773, (Rat) 59075, (Mouse) 59092
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
G-protein coupled receptor kinase activity
protein kinase C binding
protein binding
ATP binding
phospholipid binding
lipid binding
kinase activity
transferase activity
beta-adrenergic receptor kinase activity
transferase activity, transferring phosphorus-containing groups
nucleic acid binding
DNA binding
RNA binding
poly(A) RNA binding
RNA metabolism protein
non-receptor serine/threonine protein kinase
apoptotic process
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
tachykinin receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
regulation of signal transduction
Wnt signaling pathway
negative regulation of apoptotic process
fat cell differentiation
protein autophosphorylation
regulation of cell cycle
desensitization of G-protein coupled receptor protein signaling pathway
protein phosphorylation
phosphorylation
termination of G-protein coupled receptor signaling pathway
response to drug
negative regulation of mRNA splicing, via spliceosome
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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