Invitrogen

GRK5 Polyclonal Antibody

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GRK5 Antibody in Immunohistochemistry (IHC) — Immunohistochemical analysis of human placenta tissue using a G Protein-Coupled Receptor Kinase 5 polyclonal antibody (Product # PA5-23189) at 20 µg/mL dilution.

GRK5 Antibody in Western Blot (WB) — Western blot analysis of GRK5 in human liver lysate in the 1) absence, 2) presence of immunizing peptide, 3) mouse and 4) rat liver using a G Protein-Coupled Receptor Kinase 5 polyclonal antibody (Product # PA5-23189) at 0.5 µg/mL (human), 4.0 µg/mL (mouse) and 2 µg/mL (rat).

Product Details

Tested Applications

Dilution

Immunohistochemistry (Paraffin) (IHC (P))

20 µg/mL

Western Blot (WB)

0.5-4 µg/mL

Product Specifications

Species Reactivity

Bovine, Human, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide (379 IEGQSPFRGRKEKVKREE 396) of G Protein-Coupled Receptor Kinase 5 protein.

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 0.2% gelatin

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2540715

Target Information

GRK5 is a 590 amino acid protein belonging to the G protein-coupled receptor kinase family and consisting of AGC-kinase C-terminal, protein kinase and RGS domains. It phosphorylates the activated forms of G protein-coupled receptors, thus initiating their deactivation. It also phosphorylates the human substance P receptor and plays a role in regulating the motility of polymorphonuclear leukocytes (PMNs). It contains a membrane binding motif consisting of a group of hydrophobic amino acids that mediates its plasma membrane (PM) localization. GRK5 is expressed in heart, placenta, lung, skeletal muscle, brain, liver, pancreas and kidney.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.