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Bioss
GRM2/GRM4 Polyclonal Antibody
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Product Details
BS-2139R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human GRM2+GRM4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
L glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein coupled receptor, family C, group 1, member B; G protein-coupled receptor; G protein-coupled receptor GRM4; G protein-coupled receptor, family C, group 1, member B; G protein-coupled receptor, family C, group 1, member D; glutamate receptor homolog; glutamate receptor, metabotropic 2; glutamate receptor, metabotropic 4; Metabotropic glutamate receptor 2; Metabotropic glutamate receptor 4; mGluR2; mGluR4; unnamed protein product
Gene Aliases: 4930441L02Rik; GLUR2; GPRC1B; GPRC1D; GRM2; GRM4; mGlu2; mGlu4; MGLUR2; MGLUR4; mGluR7
UniProt ID: (Human) Q14416, (Human) Q14833, (Mouse) Q14BI2, (Rat) P31421, (Rat) P31423, (Mouse) Q68EF4
Entrez Gene ID: (Human) 2912, (Human) 2914, (Mouse) 108068, (Rat) 24415, (Rat) 24417, (Mouse) 268934
group II metabotropic glutamate receptor activity
G-protein coupled receptor activity
calcium channel regulator activity
protein binding
glutamate receptor activity
scaffold protein binding
adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
signal transducer activity
group III metabotropic glutamate receptor activity
calmodulin binding
calcium-dependent protein binding
G-protein coupled receptor
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
gene expression
glutamate secretion
regulation of glutamate secretion
regulation of dopamine secretion
cellular response to stress
behavioral response to nicotine
response to cocaine
positive regulation of protein kinase B signaling
regulation of synaptic transmission, glutamatergic
long term synaptic depression
glutamate homeostasis
presynaptic modulation of chemical synaptic transmission
regulation of response to drug
neurotransmitter secretion
positive regulation of MAPK cascade
regulation of neuron apoptotic process
regulation of neurotransmitter secretion
activation of MAPK activity
learning
negative regulation of cell proliferation
gamma-aminobutyric acid secretion
neuron projection development
synaptic transmission, glutamatergic
negative regulation of apoptotic process
negative regulation of synaptic transmission
synaptic transmission, GABAergic
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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