Proteintech

GRP78/BIP Polyclonal Antibody

Product Image Gallery

GRP78/BIP Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( 4% PFA) fixed HepG2 cells using 11587-1-AP (GRP78/BIP antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

GRP78/BIP Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using 11587-1-AP (GRP78/BIP antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

GRP78/BIP Antibody in Western Blot (WB) — Rat liver tissue were subjected to SDS PAGE followed by western blot with 11587-1-AP (GRP78/BIP antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours.

GRP78/BIP Antibody in Flow Cytometry (Flow) — 1X10^6 HeLa cells were stained with 0.2ug GRP78/BIP antibody (11587-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) with dilution 1:1000.

GRP78/BIP Antibody in Immunoprecipitation (IP) — IP result of anti-GRP78/BIP (IP:11587-1-AP, 3ug; Detection:11587-1-AP 1:1000) with MCF-7 cells lysate 3250ug.

Product Details

11587-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:3000-1:8000	View 88 publications 88 publications
Immunohistochemistry (IHC)	-	View 13 publications 13 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-
Immunocytochemistry (ICC/IF)	1:50-1:500	View 11 publications 11 publications
Flow Cytometry (Flow)	0.2 µg/1x10^6 cells	-
Immunoprecipitation (IP)	0.5-4.0 µg	View 2 publications 2 publications
Miscellaneous PubMed (Misc)	-	View 8 publications 8 publications

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Deer, Fish, Hamster, Human, Mouse, Rat, Zebrafish
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	GRP78/BIP Fusion Protein Ag2188 (351-654 aa encoded by BC020235) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.57 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

11587-1-AP antibody recognizes one or two bands with MW 70-78 kDa for the signal peptide of GRP78 protein.

Immunogen sequence: LKKSDIDEI VLVGGSTRIP KIQQLVKEFF NGKEPSRGIN PDEAVAYGAA VQAGVLSGDQ DTGDLVLLDV CPLTLGIETV GGVMTKLIPR NTVVPTKKSQ IFSTASDNQP TVTIKVYEGE RPLTKDNHLL GTFDLTGIPP APRGVPQIEV TFEIDVNGIL RVTAEDKGTG NKNKITITND QNRLTPEEIE RMVNDAEKFA EEDKKLKERI DTRNELESYA YSLKNQIGDK EKLGGKLSSE DKETMEKAVE EKIEWLESHQ DADIEDFKAK KKELEEIVQP IISKLYGSAG PPPTGEEDTA EKDEL (351-654 aa encoded by BC020235)

Target Information

GRP78 is a 78 kDa glucose regulated protein that belongs to the family of heat shock proteins that include HSP70. GRP78 is a resident protein of the endoplasmic reticulum (ER) and associates transiently with a variety of newly synthesized secretory and membrane proteins. GRP78 may also interact with mutant and misfolded proteins, marking them for degradation. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C-terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP94) and protein disulfide isomerase (PDI). The KDEL signal is recognized by the KDEL receptor and this interaction ensures recycling of escaped ER proteins back to the ER. GRP78's involvement in correct folding of proteins and degradation of misfolded proteins is via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate. GRP78 is critical for maintenance of cell homeostasis and the prevention of apoptosis. GRP78 protein levels have been shown to be a reliable biomarker of hypoglycemia and serves a neuroprotective function in neurons exposed to glutamate and oxidative stress. GRP78 levels are reduced in the brains of Alzheimer's Disease patients, and decreased expression of GRP78 is found associated with missense mutations in the human presenilin-1 (PS1) gene. Further, the induction of the GRP78 protein has been associated with the development of drug-resistance to antitumor drugs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Palmitic acid aggravates inflammation of pancreatic acinar cells by enhancing unfolded protein response induced CCAAT-enhancer-binding protein β-CCAAT-enhancer-binding protein α activation.

The international journal of biochemistry & cell biology

Wu J,Hu G,Lu Y,Zheng J,Chen J,Wang X,Zeng Y

Sat Oct 01 00:00:00 EDT 2016

Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.

Chemical research in toxicology

Liu Z,Shi Q,Song X,Wang Y,Wang Y,Song E,Song Y

Mon Sep 19 00:00:00 EDT 2016

PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.

Drug design, development and therapy

Yao Z,Sun B,Hong Q,Yan J,Mu D,Li J,Sheng H,Guo H

Thu Sep 15 00:00:00 EDT 2016

Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice.

Brain research

Bai X,Liu S,Yuan L,Xie Y,Li T,Wang L,Wang X,Zhang T,Qin S,Song G,Ge L,Wang Z

Thu Sep 01 00:00:00 EDT 2016

Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice.

Brain research

Bai X,Liu S,Yuan L,Xie Y,Li T,Wang L,Wang X,Zhang T,Qin S,Song G,Ge L,Wang Z

Thu Sep 01 00:00:00 EDT 2016

Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease.

Molecular psychiatry

Sharoar MG,Shi Q,Ge Y,He W,Hu X,Perry G,Zhu X,Yan R

Thu Sep 01 00:00:00 EDT 2016

Design, purification and assessment of GRP78 binding peptide-linked Subunit A of Subtilase cytotoxic for targeting cancer cells.

BMC biotechnology

Zhang L,Li Z,Shi T,La X,Li H,Li Z

Thu Sep 01 00:00:00 EDT 2016

Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism.

Scientific reports

Zhou L,Ding S,Li Y,Wang L,Chen W,Bo T,Wu K,Li C,Liu X,Zhao J,Xu C,Gao L

Fri Aug 19 00:00:00 EDT 2016

Cathelicidin PR-39 peptide inhibits hypoxia/reperfusion-induced kidney cell apoptosis by suppression of the endoplasmic reticulum-stress pathway.

Acta biochimica et biophysica Sinica

Liu J,Xue W,Xiang H,Zheng J,Zhao Y,Jiao L,Jiao Z

Mon Aug 01 00:00:00 EDT 2016

A Health Threat to Bystanders Living in the Homes of Smokers: How Smoke Toxins Deposited on Surfaces Can Cause Insulin Resistance.

PloS one

Adhami N,Starck SR,Flores C,Martins Green M

Mon Jul 18 00:00:00 EDT 2016

Metabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null Mice.

PloS one

Aumailley L,Garand C,Dubois MJ,Johnson FB,Marette A,Lebel M

Thu Jun 02 00:00:00 EDT 2016

Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Hu H,Wang C,Jin Y,Meng Q,Liu Q,Liu K,Sun H

Sun May 01 00:00:00 EDT 2016

Japanese encephalitis virus induces apoptosis by the IRE1/JNK pathway of ER stress response in BHK-21 cells.

Archives of virology

Huang M,Xu A,Wu X,Zhang Y,Guo Y,Guo F,Pan Z,Kong L

Tue Mar 01 00:00:00 EST 2016

Effects of Placental Ischemia Are Attenuated by 1,25-Dihydroxyvitamin D Treatment and Associated with Reduced Apoptosis and Increased Autophagy.

DNA and cell biology

Tian X,Ma S,Wang Y,Hou L,Shi Y,Yao M,Wang X,Zhang H,Jiang L

Mon Feb 01 00:00:00 EST 2016

Translation from the 5' untranslated region shapes the integrated stress response.

Science (New York, N.Y.)

Starck SR,Tsai JC,Chen K,Shodiya M,Wang L,Yahiro K,Martins-Green M,Shastri N,Walter P

Fri Jan 29 00:00:00 EST 2016

The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma.

Oncotarget

Dadey DY,Kapoor V,Khudanyan A,Urano F,Kim AH,Thotala D,Hallahan DE

Tue Jan 12 00:00:00 EST 2016

Impact of vitamin C on the cardiometabolic and inflammatory profiles of mice lacking a functional Werner syndrome protein helicase.

Experimental gerontology

Aumailley L,Dubois MJ,Garand C,Marette A,Lebel M

Tue Dec 01 00:00:00 EST 2015

Impaired unfolded protein response in the degeneration of cochlea cells in a mouse model of age-related hearing loss.

Experimental gerontology

Wang W,Sun Y,Chen S,Zhou X,Wu X,Kong W,Kong W

Thu Oct 01 00:00:00 EDT 2015

Impaired unfolded protein response in the degeneration of cochlea cells in a mouse model of age-related hearing loss.

Experimental gerontology

Wang W,Sun Y,Chen S,Zhou X,Wu X,Kong W,Kong W

Thu Oct 01 00:00:00 EDT 2015

Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum.

American journal of physiology. Renal physiology

Liu KM,Chuang SM,Long CY,Lee YL,Wang CC,Lu MC,Lin RJ,Lu JH,Jang MY,Wu WJ,Ho WT,Juan YS

Sat Aug 15 00:00:00 EDT 2015

Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum.

American journal of physiology. Renal physiology

Liu KM,Chuang SM,Long CY,Lee YL,Wang CC,Lu MC,Lin RJ,Lu JH,Jang MY,Wu WJ,Ho WT,Juan YS

Sat Aug 15 00:00:00 EDT 2015

Legionella suppresses the host unfolded protein response via multiple mechanisms.

Nature communications

Treacy-Abarca S,Mukherjee S

Wed Jul 29 00:00:00 EDT 2015

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions.

Science signaling

Kanekura K,Ma X,Murphy JT,Zhu LJ,Diwan A,Urano F

Tue Jun 23 00:00:00 EDT 2015

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions.

Science signaling

Kanekura K,Ma X,Murphy JT,Zhu LJ,Diwan A,Urano F

Tue Jun 23 00:00:00 EDT 2015

Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release.

Chemical research in toxicology

Xu D,Su C,Song X,Shi Q,Fu J,Hu L,Xia X,Song E,Song Y

Mon Jun 15 00:00:00 EDT 2015

Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats.

Phytotherapy research : PTR

Yu H,Zheng L,Xu L,Yin L,Lin Y,Li H,Liu K,Peng J

Sun Feb 01 00:00:00 EST 2015

Knockdown of glucose-regulated protein 78/binding immunoglobulin heavy chain protein expression by asymmetric small interfering RNA induces apoptosis in prostate cancer cells and attenuates migratory capability.

Molecular medicine reports

Lu T,Yang W,Wang Z,Hu Z,Zeng X,Yang C,Wang Y,Zhang Y,Li F,Liu Z,Wang D,Ye Z

Thu Jan 01 00:00:00 EST 2015

Protective effects of dioscin against alcohol-induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sat Mar 01 00:00:00 EST 2014

Protective effects of dioscin against alcohol-induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sat Mar 01 00:00:00 EST 2014

The resveratrol attenuates ethanol-induced hepatocyte apoptosis via inhibiting ER-related caspase-12 activation and PDE activity in vitro.

Alcoholism, clinical and experimental research

Liu LQ,Fan ZQ,Tang YF,Ke ZJ

Sat Mar 01 00:00:00 EST 2014

Selenium deficiency is associated with endoplasmic reticulum stress in a rat model of cardiac malfunction.

Biological trace element research

Wang SQ,Niu XL,Liu ZW,Zhu YH,Gao DF

Sun Dec 01 00:00:00 EST 2013

Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Dong D,Zhang S,Yin L,Tang X,Xu Y,Han X,Qi Y,Peng J

Sun Dec 01 00:00:00 EST 2013

Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic reticulum stress-induced apoptosis in diabetic cardiomyopathy.

Cardiovascular diabetology

Liu ZW,Zhu HT,Chen KL,Dong X,Wei J,Qiu C,Xue JH

Sat Nov 02 00:00:00 EDT 2013

ABCG1 deficiency promotes endothelial apoptosis by endoplasmic reticulum stress-dependent pathway.

The journal of physiological sciences : JPS

Xue J,Wei J,Dong X,Zhu C,Li Y,Song A,Liu Z

Fri Nov 01 00:00:00 EDT 2013

Exposure to tributyltin induces endoplasmic reticulum stress and the unfolded protein response in zebrafish.

Aquatic toxicology (Amsterdam, Netherlands)

Komoike Y,Matsuoka M

Tue Oct 15 00:00:00 EDT 2013

Upregulation of phosphorylated HSP27, PRDX2, GRP75, GRP78 and GRP94 in acquired middle ear cholesteatoma growth.

International journal of molecular sciences

Ho KY,Yeh TS,Huang HH,Hung KF,Chai CY,Chen WT,Tsai SM,Chang NC,Chien CY,Wang HM,Wu YJ

Thu Jul 11 00:00:00 EDT 2013

The alteration of protein profile induced by cigarette smoking via oxidative stress in mice epididymis.

The international journal of biochemistry & cell biology

Zhu Z,Xu W,Dai J,Chen X,Zhao X,Fang P,Yang F,Tang M,Wang Z,Wang L,Ma D,Qaio Z

Fri Mar 01 00:00:00 EST 2013

Cell intrinsic role of COX-2 in pancreatic cancer development.

Molecular cancer therapeutics

Hill R,Li Y,Tran LM,Dry S,Calvopina JH,Garcia A,Kim C,Wang Y,Donahue TR,Herschman HR,Wu H

Mon Oct 01 00:00:00 EDT 2012

Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes.

Journal of proteomics

Kim HJ,Kang UB,Lee H,Jung JH,Lee ST,Yu MH,Kim H,Lee C

Wed Jun 06 00:00:00 EDT 2012

Proteomic analysis of anti-tumor effects of 11-dehydrosinulariolide on CAL-27 cells.

Marine drugs

Liu CI,Chen CC,Chen JC,Su JH,Huang HH,Chen JY,Wu YJ

Fri Feb 10 00:00:00 EST 2012

Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3.

PloS one

Gao XC,Zhou CJ,Zhou ZR,Zhang YH,Zheng XM,Song AX,Hu HY

Mon Nov 28 00:00:00 EST 2011

Bioinformatics

Protein Aliases: 78 kDa glucose-regulated protein; Binding-immunoglobulin protein; BiP; Endoplasmic reticulum chaperone BiP; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; epididymis secretory sperm binding protein Li 89n; FLJ26106; glucose regulated protein, 78 kDa; glucose-regulated protein, 78kDa; GRP 78; GRP-78; heat shock 70 kDa protein 5; heat shock 70kD protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Heat shock protein 70 family protein 5; Heat shock protein family A member 5; HSP70 family protein 5; HSPA 5; Immunoglobulin heavy chain-binding protein; Steroidogenesis-activator polypeptide; XAP-1 antigen

Gene Aliases: AL022860; AU019543; baffled; BIP; D2Wsu141e; D2Wsu17e; GRP78; HEL-S-89n; Hsce70; HSPA5; mBiP; MIF2; SEZ-7; Sez7

UniProt ID: (Human) P11021, (Rat) P06761, (Mouse) P20029

Entrez Gene ID: (Human) 3309, (Rat) 25617, (Mouse) 14828

Function(s)