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Proteintech
GSDMD Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-20770
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GSDMD fusion protein Ag14757
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: HERHLRQPE HKVLQQLRSR GDNVYVVTEV LQTQKEVEVT RTHKREGSGR FSLPGATCLQ GEGQGHLSQK KTVTIPSGST LAFRVAQLVI DSDLDVLLFP DKKQRTFQPP ATGHKRSTSE GAWPQLPSGL SMMRCLHNFL TDGVPAEGAF TEDFQGLRAE VETISKELEL LDRELCQLLL EGLEGVLRDQ LALRALEEAL EQGQSLGPVE PLDGPAGAVL ECLVLSSGML VPELAIPVVY LLGALTMLSE TQHKLLAEAL ESQTLLGPLE LVGSLLEQSA PWQERSTMSL PPGLLGNSWG EGAPAWVLLD ECGLELGEDT PHVCWEPQAQ GRMCALYASL ALLSGLSQEP H
Target Information
GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as, non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, GSDMD moves to the plasma membrane where it strongly binds to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine. GSDMD also exhibits bactericidal activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: gasdermin domain containing 1; Gasdermin domain-containing protein 1; Gasdermin-D
Gene Aliases: 1810036L03Rik; AW558049; DF5L; DFNA5L; FKSG10; GSDMD; GSDMDC1; M2-4
UniProt ID: (Human) P57764, (Mouse) Q9D8T2
Entrez Gene ID: (Human) 79792, (Rat) 315084, (Mouse) 69146
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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