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Invitrogen

GSK3 alpha Polyclonal Antibody

View all (26) GSK3 alpha antibodies

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GSK3 alpha Polyclonal Antibody

Product Details

PA5-115331

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:200
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human GSK3A(Accession P49840), corresponding to amino acid residues M1-T46.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899967

Product Specific Information

Antibody detects endogenous levels of total GSK3 alpha.

Target Information

Glycogen synthase kinase 3 alpha (GSK3A) is a multifunctional protein serine/threonine kinase implicated in the control of several regulatory proteins and transcription factors. (GSK3A Alias: DKFZp686D0638). Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp686D0638; FA; Factor A; Glycogen synthase kinase-3 alpha; GSK-3 alpha; gsk-3-alpha; OTTHUMP00000198368; Serine/threonine-protein kinase GSK3A

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Gene Aliases: 2700086H06Rik; GSK3A

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UniProt ID: (Human) P49840, (Rat) P18265, (Mouse) Q2NL51

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Entrez Gene ID: (Human) 2931, (Rat) 50686, (Mouse) 606496

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity receptor binding protein binding ATP binding kinase activity transferase activity protein kinase A catalytic subunit binding tau protein binding tau-protein kinase activity protein serine kinase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
regulation of systemic arterial blood pressure cardiac left ventricle morphogenesis glycogen metabolic process nervous system development insulin receptor signaling pathway negative regulation of signal transduction positive regulation of autophagy positive regulation of gene expression negative regulation of UDP-glucose catabolic process regulation of neuron projection development Wnt signaling pathway cell migration viral protein processing cell differentiation positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway negative regulation of TOR signaling positive regulation of proteasomal ubiquitin-dependent protein catabolic process cellular response to insulin stimulus cellular response to interleukin-3 proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of neuron apoptotic process negative regulation of glycogen biosynthetic process positive regulation of protein catabolic process positive regulation of heart contraction positive regulation of transcription from RNA polymerase II promoter negative regulation of glucose import negative regulation of insulin receptor signaling pathway excitatory postsynaptic potential negative regulation of cell growth involved in cardiac muscle cell development regulation of microtubule cytoskeleton organization cellular response to lithium ion cellular response to glucocorticoid stimulus positive regulation of adrenergic receptor signaling pathway negative regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway autosome genomic imprinting beta-arrestin-dependent dopamine receptor signaling pathway positive regulation of substrate adhesion-dependent cell spreading positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitophagy cellular response to oxygen-containing compound positive regulation of beta-amyloid formation positive regulation of protein targeting to mitochondrion positive regulation of establishment of protein localization negative regulation of type B pancreatic cell development negative regulation of glycogen (starch) synthase activity regulation of gene expression by genetic imprinting protein phosphorylation signal transduction positive regulation of peptidyl-threonine phosphorylation positive regulation of cAMP biosynthetic process positive regulation of peptidyl-serine phosphorylation hypermethylation of CpG island negative regulation of transferase activity cellular response to organic cyclic compound positive regulation of glycogen (starch) synthase activity carbohydrate metabolic process phosphorylation regulation of mitophagy
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