Immunogen sequence: YQARLAETR ELVAIKKVLQ DKRFKNRELQ IMRKLDHCNI VRLRYFFYSS GEKKDELYLN LVLEYVPETV YRVARHFTKA KLTIPILYVK VYMYQLFRSL AYIHSQGVCH RDIKPQNLLV DPDTAVLKLC DFGSAKQLVR GEPNVSYICS RYYRAPELIF GATDYTSSID VWSAGCVLAE LLLGQPIFPG DSGVDQLVEI IKVLGTPTRE QIREMNPNYT EFKFPQIKAH PWTKVFKSRT PPEAIALCSS LLEYTPSSRL SPLEACAHSF FDELRCLGTQ LPNNRPLPPL FNFSAGELSI QPSLNAILIP PHLRSPAGTT TLTPSSQALT ETPTSSDWQS TDATPTLTNS S (134-483 aa encoded by BC027984)
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.
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Protein Aliases: DKFZp686D0638; FA; Factor A; Glycogen synthase kinase-3 alpha; GSK-3 alpha; gsk-3-alpha; OTTHUMP00000198368; Serine/threonine-protein kinase GSK3A
Gene Aliases: 2700086H06Rik; GSK3A
Molecular Function: non-receptor serine/threonine protein kinase