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Product Details
15113-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GSK3B Fusion Protein Ag7101 (1-351 aa encoded by BC000251)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognize the 2 isoforms of GSK3B.
Immunogen sequence: MSGRPRTTS FAESCKPVQQ PSAFGSMKVS RDKDGSKVTT VVATPGQGPD RPQEVSYTDT KVIGNGSFGV VYQAKLCDSG ELVAIKKVLQ DKRFKNRELQ IMRKLDHCNI VRLRYFFYSS GEKKDEVYLN LVLDYVPETV YRVARHYSRA KQTLPVIYVK LYMYQLFRSL AYIHSFGICH RDIKPQNLLL DPDTAVLKLC DFGSAKQLVR GEPNVSYICS RYYRAPELIF GATDYTSSID VWSAGCVLAE LLLGQPIFPG DSGVDQLVEI IKVLGTPTRE QIREMNPNYT EFKFPQIKAH PWTKDSSGTG HFTSGVRVFR PRTPPEAIAL CSRLLEYTPT ARLTPLEACA HS (1-351 aa encoded by BC000251)
Target Information
GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development and body pattern formation. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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