This antibody recognize the 2 isoforms of GSK3B.
Menin is a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Two variants of the shorter transcript have been identified where alternative splicing affects the CDS. Five variants where alternative splicing takes place in the 5' UTR have also been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 2.7.11.26; FA; Factor A; glycogen synthase kinase 3 beta variant 1; glycogen synthase kinase 3 beta variant 2; glycogen synthase kinase 3 beta variant 3; glycogen synthase kinase 3 beta variant 4; glycogen synthase kinase 3 beta variant 5; Glycogen synthase kinase-3 beta; GSK 3 beta; GSK 3B; GSK-3 beta; GSK-3 beta GSK3B; GSK-3b; GSK3 beta; GSK3beta isoform; Serine/threonine-protein kinase GSK3B
Gene Aliases: 7330414F15Rik; 8430431H08Rik; C86142; fb68h05; fk80d11; GSK-3; GSK-3[b]; GSK-3beta; GSK3; GSK3B; GSK3beta; wu:fb68h05; wu:fk80d11
UniProt ID: (Human) P49841, (Mouse) Q9WV60, (Rat) P18266
Entrez Gene ID: (Human) 2932, (Pig) 100126852, (Mouse) 56637, (Rat) 84027, (Zebrafish) 30654
Molecular Function:
kinase
non-receptor serine/threonine protein kinase
protein kinase
transferase
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