Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:2,000 | - |
Immunohistochemistry (PFA fixed) (IHC (PFA)) |
1:200 | - |
Immunocytochemistry (ICC/IF) |
Assay-Dependent | - |
Product Specifications | |
---|---|
Species Reactivity |
Bovine, Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide corresponding to the sequence near the C-terminus of human GSK-3Beta |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1.3 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS, pH 7.4 |
Contains |
no preservative |
Storage conditions |
-20°C |
RRID |
AB_2735886 |
GSK3B is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 2.7.11.26; FA; Factor A; Glycogen synthase kinase-3 beta; glycogen synthase kinase-3 beta splice variant X1; glycogen synthase kinase-3 beta splice variant X2; glycogen synthase kinase-3 beta splice variant X3; GSK 3 beta; GSK 3B; GSK-3 beta; GSK-3 beta GSK3B; GSK-3b; GSK-3beta; GSK3 beta; GSK3beta isoform; Serine/threonine-protein kinase GSK3B
Gene Aliases: 7330414F15Rik; 8430431H08Rik; C86142; GSK-3; GSK-3beta; GSK3; GSK3B; GSK3beta
UniProt ID: (Human) P49841, (Mouse) Q9WV60, (Rat) P18266
Entrez Gene ID: (Human) 2932, (Bovine) 790875, (Mouse) 56637, (Rat) 84027
Molecular Function:
non-receptor serine/threonine protein kinase
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