Search
Invitrogen
GSTM1/GSTM2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-18335
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (CVFSKMAVWGNK) corresponding to the C-terminus amino acids of GSTM1GSTM2 (aa 208-218).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1,000.
Target Information
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; glutathione S-alkyltransferase; glutathione S-alkyltransferase M2; glutathione S-aralkyltransferase; glutathione S-aralkyltransferase M2; glutathione S-aryltransferase; glutathione S-aryltransferase M2; glutathione S-transferase 4; glutathione S-transferase M1; glutathione S-transferase M2 (muscle); Glutathione S-transferase Mu 1; Glutathione S-transferase Mu 2; glutathione S-transferase mu 2 (muscle); GST class-mu 1; GST class-mu 2; GST HB subunit 4; GST, muscle; GSTM1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GSTM2-2; GTH4; HB subunit 4; MGC117303; MGC26563; S-(hydroxyalkyl)glutathione lyase; S-(hydroxyalkyl)glutathione lyase M2; unnamed protein product
Gene Aliases: GST1; GST4; GSTM; GSTM1; GSTM1-1; GSTM1a-1a; GSTM1b-1b; GSTM2; GSTM2-2; GTH4; GTHMUS; GTM1; H-B; MU; MU-1
UniProt ID: (Human) P09488, (Human) P28161
Entrez Gene ID: (Human) 2944, (Human) 2946
lipid metabolic process
glutathione metabolic process
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
nitrobenzene metabolic process
xenobiotic catabolic process
linoleic acid metabolic process
hepoxilin biosynthetic process
relaxation of cardiac muscle
cellular detoxification of nitrogen compound
cellular response to caffeine
cellular oxidant detoxification
prostaglandin metabolic process
glutathione derivative biosynthetic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support