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Invitrogen
GSTM3 Polyclonal Antibody
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Product Details
PA5-106414
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GSTM3(Accession P21266), corresponding to amino acid residues F192-C225.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total GSTM3.
Target Information
Glutathione S-transferase M3 (brain), also known as GSTM3, is an enzyme which in humans is encoded by theGSTM3 gene. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13. 3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain GST; brain type mu-glutathione S-transferase; glutathione S-alkyltransferase M3; glutathione S-aralkyltransferase M3; glutathione S-aryltransferase M3; Glutathione S-transferase GT9.3; glutathione S-transferase M3 (brain); Glutathione S-transferase Mu 3; glutathione S-transferase mu 3 (brain); glutathione S-transferase, Mu-3; GST class-mu 3; GSTM3-3; hGSTM3-3; S-(hydroxyalkyl)glutathione lyase M3
Gene Aliases: Fsc2; GST5; GSTB; GSTM3; GSTM3-3; GTM3; mGSTM5
UniProt ID: (Human) P21266, (Mouse) P19639
Entrez Gene ID: (Human) 2947, (Mouse) 14864
glutathione metabolic process
establishment of blood-nerve barrier
nitrobenzene metabolic process
xenobiotic catabolic process
response to estrogen
cellular detoxification of nitrogen compound
glutathione derivative biosynthetic process
metabolic process
cellular response to drug
cellular response to organic cyclic compound
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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