Proteintech

GSTO1 Polyclonal Antibody

GSTO1 Antibody in Immunocytochemistry (ICC/IF)

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GSTO1 Antibody (15124-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using GSTO1 antibody 15124-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

GSTO1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

GSTO1 Antibody in Immunoprecipitation (IP)

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Product Details

15124-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GSTO1 Fusion Protein Ag7199 (1-241 aa encoded by BC000127)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody detects both monomer (27-30 kDa) and dimer forms of GSTO1 (54-64 kDa).

Immunogen sequence: MSGESARSL GKGSAPPGPV PEGSIRIYSM RFCPFAERTR LVLKAKGIRH EVININLKNK PEWFFKKNPF GLVPVLENSQ GQLIYESAIT CEYLDEAYPG KKLLPDDPYE KACQKMILEL FSKVPSLVGS FIRSQNKEDY AGLKEEFRKE FTKLEEVLTN KKTTFFGGNS ISMIDYLIWP WFERLEAMKL NECVDHTPKL KLWMAAMKED PTVSALLTSE KDWQGFLELY LQNSPEACDY GL (1-241 aa encoded by BC000127)

Target Information

The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Nucleophilic covalent ligand discovery for the cysteine redoxome.

Nature chemical biology

Fu L,Jung Y,Tian C,Ferreira RB,Cheng R,He F,Yang J,Carroll KS

Wed Nov 01 00:00:00 UTC 2023

ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation.

The Journal of experimental medicine

Li S,Wang L,Xu Z,Huang Y,Xue R,Yue T,Xu L,Gong F,Bai S,Wu Q,Liu J,Lin B,Zhang H,Xue Y,Xu P,Hou J,Yang X,Jin T,Zhou R,Lou J,Xu T,Bai L

Mon Sep 06 00:00:00 UTC 2021

ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation.

The Journal of experimental medicine

Li S,Wang L,Xu Z,Huang Y,Xue R,Yue T,Xu L,Gong F,Bai S,Wu Q,Liu J,Lin B,Zhang H,Xue Y,Xu P,Hou J,Yang X,Jin T,Zhou R,Lou J,Xu T,Bai L

Mon Sep 06 00:00:00 UTC 2021

TMT-based quantitative proteomic analysis of porcine muscle associated with postmortem meat quality.

Food chemistry

Hou X,Liu Q,Meng Q,Wang L,Yan H,Zhang L,Wang L

Fri Oct 30 00:00:00 UTC 2020

GSTO1 regulates insulin biosynthesis in pancreatic β cells.

Biochemical and biophysical research communications

Wang L,Lei L,Xu T,Wang Y

Thu Apr 16 00:00:00 UTC 2020

GSTO1 regulates insulin biosynthesis in pancreatic β cells.

Biochemical and biophysical research communications

Wang L,Lei L,Xu T,Wang Y

Thu Apr 16 00:00:00 UTC 2020

GSTO1 acts as a mediator in sodium fluoride-induced alterations of learning and memory related factors expressions in the hippocampus cell line.

Chemosphere

Wang J,Gao Y,Cheng X,Yang J,Zhao Y,Xu H,Zhu Y,Yan Z,Manthari RK,Ommati MM,Wang J

Mon Jul 01 00:00:00 UTC 2019

Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects.

Neurotoxicology

Liu D,Xue J,Liu Y,Gu H,Wei X,Ma W,Luo W,Ma L,Jia S,Dong N,Huang J,Wang Y,Yuan Z

Sat Dec 01 00:00:00 UTC 2018

Inhibition of NRF2 signaling and increased reactive oxygen species during embryogenesis in a rat model of retinoic acid-induced neural tube defects.

Neurotoxicology

Liu D,Xue J,Liu Y,Gu H,Wei X,Ma W,Luo W,Ma L,Jia S,Dong N,Huang J,Wang Y,Yuan Z

Sat Dec 01 00:00:00 UTC 2018

Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection.

Journal of proteomics

Zhang D,Sun X,Ren L,Yang C,Liu X,Zhang H,Jiang Y,Hu X

Thu Aug 30 00:00:00 UTC 2018

Proteomic profiling of human decidual immune proteins during Toxoplasma gondii infection.

Journal of proteomics

Zhang D,Sun X,Ren L,Yang C,Liu X,Zhang H,Jiang Y,Hu X

Thu Aug 30 00:00:00 UTC 2018

The interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine on urothelial carcinogenesis in mice.

PloS one

Dai YC,Wang SC,Haque MM,Lin WH,Lin LC,Chen CH,Liu YW

Thu Oct 19 00:00:00 UTC 2017

The interaction of arsenic and N-butyl-N-(4-hydroxybutyl)nitrosamine on urothelial carcinogenesis in mice.

PloS one

Dai YC,Wang SC,Haque MM,Lin WH,Lin LC,Chen CH,Liu YW

Thu Oct 19 00:00:00 UTC 2017

Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals.

The Biochemical journal

Tobe R,Carlson BA,Huh JH,Castro NP,Xu XM,Tsuji PA,Lee SG,Bang J,Na JW,Kong YY,Beaglehole D,Southon E,Seifried H,Tessarollo L,Salomon DS,Schweizer U,Gladyshev VN,Hatfield DL,Lee BJ

Fri Jul 15 00:00:00 UTC 2016

Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals.

The Biochemical journal

Tobe R,Carlson BA,Huh JH,Castro NP,Xu XM,Tsuji PA,Lee SG,Bang J,Na JW,Kong YY,Beaglehole D,Southon E,Seifried H,Tessarollo L,Salomon DS,Schweizer U,Gladyshev VN,Hatfield DL,Lee BJ

Fri Jul 15 00:00:00 UTC 2016

Downregulation of glutathione S-transferase M1 protein in N-butyl-N-(4-hydroxybutyl)nitrosamine-induced mouse bladder carcinogenesis.

Toxicology and applied pharmacology

Chuang JJ,Dai YC,Lin YL,Chen YY,Lin WH,Chan HL,Liu YW

Mon Sep 15 00:00:00 UTC 2014

Downregulation of glutathione S-transferase M1 protein in N-butyl-N-(4-hydroxybutyl)nitrosamine-induced mouse bladder carcinogenesis.

Toxicology and applied pharmacology

Chuang JJ,Dai YC,Lin YL,Chen YY,Lin WH,Chan HL,Liu YW

Mon Sep 15 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: epididymis secretory protein Li 21; glutathione S-transferase like; Glutathione S-transferase omega 1-1; Glutathione S-transferase omega-1; Glutathione transferase omega 1 (GSTO 1-1) (p28); Glutathione-dependent dehydroascorbate reductase; glutathione-S-transferase like; GSTO 1-1; GSTO-1; MMA(V) reductase; Monomethylarsonic acid reductase; p28; RP11-99N20.1; S-(Phenacyl)glutathione reductase; SPG-R

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Gene Aliases: AA407097; AI194287; AU018802; GSTO 1-1; GSTO1; GSTTLP28; GSTX; Gtsttl; HEL-S-21; P28; SPG-R

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UniProt ID: (Human) P78417, (Mouse) O09131

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Entrez Gene ID: (Human) 9446, (Rat) 114846, (Mouse) 14873

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Function(s)

glutathione transferase activity protein binding oxidoreductase activity glutathione dehydrogenase (ascorbate) activity methylarsonate reductase activity transferase activity

Process(es)

metabolic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum L-ascorbic acid metabolic process L-ascorbic acid biosynthetic process xenobiotic catabolic process oxidation-reduction process negative regulation of ryanodine-sensitive calcium-release channel activity positive regulation of ryanodine-sensitive calcium-release channel activity cellular response to arsenic-containing substance glutathione metabolic process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion methylation cellular oxidant detoxification glutathione derivative biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GSTO1 Polyclonal Antibody

GSTO1 Antibody (15124-1-AP) in ICC/IF

Product Details

15124-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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