This is a rabbit polyclonal antibody produced by part of the N-terminal region of human GTF2H2.
Immunogen sequence: MDEEPERTK RWEGGYERTW EILKEDESGS LKATIEDILF KAKRKRVFEH HGQVRLGMMR HLYVVVDGSR TMEDQDLKPN RLTCTLKLLE YFVEEYFDQN PISQIGIIVT KSKRAEKLTE LSGNPRKHIT SLKKAVDMTC HGEPSLYNSL SIAMQTLKLV LYIMYN (1-165 aa encoded by B C005345)
Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a multiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFII. TFIIH (or BTF2) is a multisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of five subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34. Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: basal transcription factor 2, p44 subunit; Basic transcription factor 2 44 kDa subunit; BTF2 p44; general transcription factor II H, polypeptide 2 (44 kDa subunit); General transcription factor IIH polypeptide 2; General transcription factor IIH subunit 2; general transcription factor IIH, polypeptide 2 (44 kDa subunit); general transcription factor IIH, polypeptide 2, 44kD subunit; general transcription factor IIH, polypeptide 2, 44kDa; TFIIH basal transcription factor complex p44 subunit
Gene Aliases: 44kDa; BTF2; BTF2 p44; BTF2-p44; BTF2P44; GTF2H2; p44; T-BTF2P44; TFIIH