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Proteintech
GTF2H2 Polyclonal Antibody
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Product Details
16005-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GTF2H2 Fusion Protein Ag8653 (1-165 aa encoded by BC005345)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This is a rabbit polyclonal antibody produced by part of the N-terminal region of human GTF2H2.
Immunogen sequence: MDEEPERTK RWEGGYERTW EILKEDESGS LKATIEDILF KAKRKRVFEH HGQVRLGMMR HLYVVVDGSR TMEDQDLKPN RLTCTLKLLE YFVEEYFDQN PISQIGIIVT KSKRAEKLTE LSGNPRKHIT SLKKAVDMTC HGEPSLYNSL SIAMQTLKLV LYIMYN (1-165 aa encoded by B C005345)
Target Information
Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a multiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFII. TFIIH (or BTF2) is a multisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of five subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34. Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: basal transcription factor 2, p44 subunit; Basic transcription factor 2 44 kDa subunit; BTF2 p44; general transcription factor II H, polypeptide 2 (44 kDa subunit); General transcription factor IIH polypeptide 2; General transcription factor IIH subunit 2; general transcription factor IIH, polypeptide 2 (44 kDa subunit); general transcription factor IIH, polypeptide 2, 44kD subunit; general transcription factor IIH, polypeptide 2, 44kDa; TFIIH basal transcription factor complex p44 subunit; unnamed protein product
Gene Aliases: 44kDa; BTF2; BTF2 p44; BTF2-p44; BTF2P44; GTF2H2; p44; T-BTF2P44; TFIIH
UniProt ID: (Human) Q13888, (Mouse) Q9JIB4
Entrez Gene ID: (Human) 2966, (Mouse) 23894
protein binding
zinc ion binding
obsolete general RNA polymerase II transcription factor activity
metal ion binding
protein kinase activity
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
protein N-terminus binding
RNA metabolism protein
nucleic acid metabolism protein
general transcription factor
G-protein coupled receptor internalization
DNA repair
nucleotide-excision repair
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
cellular response to DNA damage stimulus
response to UV
regulation of transcription, DNA-templated
protein phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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