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Proteintech
GTPBP4 Polyclonal Antibody
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Product Details
13897-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Fruit fly,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GTPBP4 Fusion Protein Ag4859 (332-634 aa encoded by BC038975)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Amount
36 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KTEACDRLL AHRVETKMKG NKVNEVLNRL HLAIPTRRDD KERPPFIPEG VVARRKRMET EESRKKRERD LELEMGDDYI LDLQKYWDLM NLSEKHDKIP EIWEGHNIAD YIDPAIMKKL EELEKEEELR TAAGEYDSVS ESEDEEMLEI RQLAKQIREK KKLKILESKE KNTQGPRMPR TAKKVQRTVL EKEMRSLGVD MDDKDDAHYA VQARRSRSIT RKRKREDSAP PSSVARSGSC SRTPRDVSGL RDVKMVKKAK TMMKNAQKKM NRLGKKGEAD RHVFDMKPKH LLSGKRKAGK KDRR (332-634 aa encoded by B C038975)
Target Information
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Chronic renal failure gene protein; chronic renal failure protein; FLJ10686; FLJ10690; FLJ39774; G protein-binding protein CRFG; GTP binding protein 3; GTP-binding protein 4; GTP-binding protein NGB; Nucleolar GTP-binding protein 1; Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB); unnamed protein product
Gene Aliases: 2610028C09Rik; CRFG; Gtpbp3; GTPBP4; NGB; NOG1
UniProt ID: (Human) Q9BZE4, (Mouse) Q99ME9
Entrez Gene ID: (Human) 23560, (Mouse) 69237
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
osteoblast differentiation
negative regulation of DNA replication
negative regulation of cell proliferation
negative regulation of G2/M transition of mitotic cell cycle
negative regulation of cell-cell adhesion
negative regulation of cell migration
negative regulation of protein ubiquitination
ribosome biogenesis
ribosomal large subunit biogenesis
protein stabilization
regulation of cyclin-dependent protein serine/threonine kinase activity
metabolic process
negative regulation of collagen binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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