Proteintech

GTSE1 Polyclonal Antibody

View all (9) GTSE1 antibodies

Questions & Answers

Questions & Answers

Product Image Gallery

GTSE1 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HepG2 cells, using GTSE1 antibody 21319-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

GTSE1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 21319-1-AP ( GTSE1 antibody) at dilution of 1:200 (under 40x lens).

GTSE1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 21319-1-AP ( GTSE1 antibody) at dilution of 1:200 (under 10x lens).

GTSE1 Antibody in Western Blot (WB) — K-562 cells were subjected to SDS PAGE followed by western blot with 21319-1-AP (GTSE1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

GTSE1 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 21319-1-AP (GTSE1 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

GTSE1 Antibody in Western Blot (WB) — L02 cells were subjected to SDS PAGE followed by western blot with 21319-1-AP ( GTSE1 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

21319-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 1 publication 1 publication
Immunohistochemistry (IHC)	-	View 3 publications 3 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-
Immunocytochemistry (ICC/IF)	1:10-1:100	-

Product Specifications
Species Reactivity	Human
Published species	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	GTSE1 Fusion Protein Ag13497 (416-720 aa encoded by BC006325) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.3 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: CAWSESSQL NKTRSIRRRD SCLNSKTKVM PTPTNQFKIP KFSIGDSPDS STPKLSRAQR PQSCTSVGRV TVHSTPVRRS SGPAPQSLLS ARRVSALPTP ASRRCSGLPP MTPKTMPRAV GSPLCVPARR RSSEPRKNSA MRTEPTRESN RKTDSRLVDV SPDRGSPPSR VPQALNFSPE ESDSTFSKST ATEVAREEAK PGGDAAPSEA LLVDIKLEPL AVTPDAASQP LIDLPLIDFC DTPEAHVAVG SESRPLIDLM TNTPDMNKNV AKPSPVVGQL IDLSSPLIQL SPEADKENVD SPLLKF (416-720 aa encoded by BC006325)

Target Information

The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

High G2 and S-phase expressed 1 expression promotes acral melanoma progression and correlates with poor clinical prognosis.

Cancer science

Xu T,Ma M,Chi Z,Si L,Sheng X,Cui C,Dai J,Yu S,Yan J,Yu H,Wu X,Tang H,Yu J,Kong Y,Guo J

Fri Jun 01 00:00:00 EDT 2018

Silencing GTSE-1 expression inhibits proliferation and invasion of hepatocellular carcinoma cells.

Cell biology and toxicology

Guo L,Zhang S,Zhang B,Chen W,Li X,Zhang W,Zhou C,Zhang J,Ren N,Ye Q

Mon Aug 01 00:00:00 EDT 2016

Silencing GTSE-1 expression inhibits proliferation and invasion of hepatocellular carcinoma cells.

Cell biology and toxicology

Guo L,Zhang S,Zhang B,Chen W,Li X,Zhang W,Zhou C,Zhang J,Ren N,Ye Q

Mon Aug 01 00:00:00 EDT 2016

Expression profiling of small intestinal neuroendocrine tumors identifies subgroups with clinical relevance, prognostic markers and therapeutic targets.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Andersson E,Arvidsson Y,Swärd C,Hofving T,Wängberg B,Kristiansson E,Nilsson O

Wed Jun 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: G-2 and S-phase expressed 1; G2 and S phase-expressed protein 1; GTSE-1; Protein B99 homolog

Gene Aliases: B99; GTSE1

UniProt ID: (Human) Q9NYZ3

Entrez Gene ID: (Human) 51512

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest microtubule-based process positive regulation of cell migration proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of protein export from nucleus protein stabilization positive regulation of protein localization to nucleus regulation of cell cycle G2/M phase transition negative regulation of microtubule binding

Process(es)

molecular_function protein binding