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Proteintech
GUSB Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
16332-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GUSB Fusion Protein Ag9453 (302-651 aa encoded by BC014142)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.26 mg/mL
Amount
39 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SLEVQLTAQ TSLGPVSDFY TLPVGIRTVA VTKSQFLING KPFYFHGVNK HEDADIRGKG FDWPLLVKDF NLLRWLGANA FRTSHYPYAE EVMQMCDRYG IVVIDECPGV GLALPQFFNN VSLHHHMQVM EEVVRRDKNH PAVVMWSVAN EPASHLESAG YYLKMVIAHT KSLDPSRPVT FVSNSNYAAD KGAPYVDVIC LNSYYSWYHD YGHLELIQLQ LATQFENWYK KYQKPIIQSE YGAETIAGFH QDPPLMFTEE YQKSLLEQYH LGLDQKRRKY VVGELIWNFA DFMTEQSPTR VLGNKKGIFT RQRQPKSAAF LLRERYWKIA NETRYPHSVA KSQCLENSLF T (302-651 aa encoded by BC014142)
Target Information
The GUSB gene encodes beta-glucuronidase (EC 3.2.1.31), a lysosomal hydrolase involved in the stepwise degradation of glucuronic acid-containing glycosaminoglycans. It is a tetrameric glycoprotein composed of identical subunits. The GUSB gene is mutated in mucopolysaccharidosis type VII (MPS7; MIM 253220).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adipose storage deficiency; beta glucuronidase; beta-D-glucuronidase; beta-G1; beta-glucuronidase; beta-glucuronidase precursor; beta-glucuronidase precursor (EC 3.2.1.31); unnamed protein product
Gene Aliases: Ac2-223; asd; BG; g; Gur; Gus; Gus-r; Gus-s; Gus-t; Gus-u; Gut; MPS7
UniProt ID: (Human) P08236, (Rat) P06760, (Mouse) P12265
Entrez Gene ID: (Human) 2990, (Rat) 24434, (Mouse) 110006
skeletal system development
ossification
retinoid metabolic process
in utero embryonic development
endochondral ossification
muscle system process
chondrocyte hypertrophy
growth plate cartilage development
growth plate cartilage morphogenesis
carbohydrate metabolic process
autophagy
inflammatory response
lysosome organization
cell proliferation
protein secretion
gene expression
protein catabolic process
heparan sulfate proteoglycan catabolic process
glycosaminoglycan metabolic process
chondroitin sulfate catabolic process
hyaluronan catabolic process
osteoclast differentiation
protein localization to nucleus
multicellular organism growth
aorta development
chondrocyte proliferation
phosphatidylinositol-3-phosphate biosynthetic process
TORC1 signaling
regulation of tyrosine phosphorylation of STAT protein
response to peptide hormone
bone resorption
homeostasis of number of cells
regulation of catalytic activity
bone development
bone morphogenesis
articular cartilage development
energy homeostasis
bone growth
cranial skeletal system development
cell morphogenesis
I-kappaB kinase/NF-kappaB signaling
tumor necrosis factor-mediated signaling pathway
toll-like receptor 4 signaling pathway
glycosaminoglycan catabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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