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GYS2 Polyclonal Antibody

GYS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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GYS2 Antibody (22371-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver tissue slide using 22371-1-AP (GYS2 antibody) at dilution of 1:200 (under 40x lens).

GYS2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

22371-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:16,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

GYS2 Fusion Protein Ag18012 (604-703 aa encoded by BC126310)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YYQHARHLT LSRAFPDKFH VELTSPPTTE GFKYPRPSSV PPSPSGSQAS SPQSSDVEDE VEDERYDEEE EAERDRLNIK SPFSLSHVPH GKKKLHGEYK N (604-703 aa encoded by BC126310)

Target Information

The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.

American journal of physiology. Endocrinology and metabolism

Rome FI,Shobert GL,Voigt WC,Stagg DB,Puchalska P,Burgess SC,Crawford PA,Hughey CC

Sun Jan 01 00:00:00 UTC 2023

Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness.

Cell metabolism

Gu L,Zhu Y,Watari K,Lee M,Liu J,Perez S,Thai M,Mayfield JE,Zhang B,Cunha E Rocha K,Li F,Kim LC,Jones AC,Wierzbicki IH,Liu X,Newton AC,Kisseleva T,Lee JH,Ying W,Gonzalez DJ,Saltiel AR,Simon MC,Karin M

Tue Jun 06 00:00:00 UTC 2023

N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA.

Nature communications

Zhang X,Yin H,Zhang X,Jiang X,Liu Y,Zhang H,Peng Y,Li D,Yu Y,Zhang J,Cheng S,Yang A,Zhang R

Thu Nov 17 00:00:00 UTC 2022

N6-methyladenosine modification governs liver glycogenesis by stabilizing the glycogen synthase 2 mRNA.

Nature communications

Zhang X,Yin H,Zhang X,Jiang X,Liu Y,Zhang H,Peng Y,Li D,Yu Y,Zhang J,Cheng S,Yang A,Zhang R

Thu Nov 17 00:00:00 UTC 2022

MYCT1 alters the glycogen shunt by regulating selective translation of RACK1-mediated enzymes.

iScience

Ding DX,Wang Y,Yan W,Fu WN

Fri Mar 18 00:00:00 UTC 2022

Metabolic alterations and mitochondrial dysfunction underlie hepatocellular carcinoma cell death induced by a glycogen metabolic inhibitor.

Biochemical pharmacology

Barot S,Stephenson OJ,Priya Vemana H,Yadav A,Bhutkar S,Trombetta LD,Dukhande VV

Thu Sep 01 00:00:00 UTC 2022

Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic lipolysis in rat.

Metabolism: clinical and experimental

Liu Z,Zhang L,Qian C,Zhou Y,Yu Q,Yuan J,Lv Y,Zhang L,Chang X,Li Y,Liu Y

Tue Nov 01 00:00:00 UTC 2022

Liver fibrosis alters the molecular structures of hepatic glycogen.

Carbohydrate polymers

Wan Y,Hu Z,Liu Q,Wang L,Sullivan MA,Gilbert RG

Tue Feb 15 00:00:00 UTC 2022

Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.

Molecular metabolism

Rome FI,Hughey CC

Fri Apr 01 00:00:00 UTC 2022

Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.

Nutrients

Lin L,Zeng L,Liu A,Yuan D,Peng Y,Zhang S,Li Y,Chen J,Xiao W,Gong Z

Wed Nov 17 00:00:00 UTC 2021

Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.

Journal of food biochemistry

Xin C,Zhao M,Wang J,Wang Z

Thu Jul 01 00:00:00 UTC 2021

Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.

Nature

Keinan O,Valentine JM,Xiao H,Mahata SK,Reilly SM,Abu-Odeh M,Deluca JH,Dadpey B,Cho L,Pan A,Yu RT,Dai Y,Liddle C,Downes M,Evans RM,Lusis AJ,Laakso M,Chouchani ET,Rydén M,Saltiel AR

Mon Nov 01 00:00:00 UTC 2021

Brain-Type Glycogen Phosphorylase Is Crucial for Astrocytic Glycogen Accumulation in Chronic Social Defeat Stress-Induced Depression in Mice.

Frontiers in molecular neuroscience

Zhu Y,Fan Z,Zhao Q,Li J,Cai G,Wang R,Liang Y,Lu N,Kang J,Luo D,Tao H,Li Y,Huang J,Wu S

Fri Feb 11 00:00:00 UTC 2022

l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.

Food & function

Lin L,Zeng L,Liu A,Peng Y,Yuan D,Zhang S,Li Y,Chen J,Xiao W,Gong Z

Wed Feb 26 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: Glycogen [starch] synthase, liver; glycogen liver; Glycogen synthase 2; glycogen synthase 2 (liver); glycogen synthase, liver

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Gene Aliases: BC021322; GLYSN; GYS2; LGS

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UniProt ID: (Human) P54840, (Mouse) Q8VCB3

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Entrez Gene ID: (Human) 2998, (Mouse) 232493, (Rat) 25623

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Function(s)

glycogen (starch) synthase activity glucose binding protein homodimerization activity glycogen synthase activity, transferring glucose-1-phosphate catalytic activity transferase activity transferase activity, transferring glycosyl groups

Process(es)

glycogen biosynthetic process generation of precursor metabolites and energy response to glucose glycogen metabolic process metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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GYS2 Polyclonal Antibody

GYS2 Antibody (22371-1-AP) in IHC (P)

Product Details

22371-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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