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Bioss
Gab2 Polyclonal Antibody
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Product Details
BS-2885R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Gab2, amino acids 601-676.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Grb2 associated binder 2; GRB2-associated binder 2; GRB2-associated-binding protein 2; GRB3-3; Growth factor receptor bound protein 2-associated protein 2; PH domain-containing adaptor molecule p97; pp100
Gene Aliases: AI463667; D130058I17Rik; GAB2; KIAA0571; p97
UniProt ID: (Human) Q9UQC2, (Rat) Q9EQH1
Entrez Gene ID: (Human) 9846, (Rat) 84477, (Mouse) 14389
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
osteoclast differentiation
positive regulation of mast cell degranulation
protein kinase B signaling
integrin-mediated signaling pathway
cell migration
intracellular signal transduction
phosphatidylinositol-mediated signaling
positive regulation of signal transduction
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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