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Proteintech
Galc Polyclonal Antibody
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Product Details
11991-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Galc Fusion Protein Ag3914 (340-513 aa encoded by BC086671)
Conjugate
Form
Liquid
Concentration
0.34 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The GALC antibody targets the liposomal enzyme Galactosylceramidase (GALC), which belongs to the glycosyl hydrolase 59 family. Normal GALC mRNA encodes the 80 kDa precursor, which is processed into 50 and 30 kDa subunits.
Immunogen sequence: YYLKTVGHL EKGGSYVALT DGLGNLTIII ETMSHQHSMC IRPYLPYYNV SHQLATFTLK GSLREIQELQ VWYTKLGTPQ QRLHFKQLDT LWLLDGSGSF TLELEEDEIF TLTTLTTGRK GSYPPPPSSK PFPTNYKDDF NVEYPLFSEA PNFADQTGVF EYYMNNEDRE HRFTL (340-513 aa encoded by BC086671)
Target Information
This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3.2.1.46; beta-galactosidase; Galactocerebrosidase; Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta-galactosidase; galactosylceraminidase; GALCERase; testis tissue sperm-binding protein Li 88E; testis tissue sperm-binding protein Li 89A
Gene Aliases: 2310068B06Rik; A930008M05Rik; AW212969; AW413532; Gacy; GALC; twi; twitcher
UniProt ID: (Human) B7Z7Z2, (Mouse) P54818
Entrez Gene ID: (Human) 2581, (Rat) 314360, (Mouse) 14420
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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