Immunogen sequence: SSGQPSATGA YPATGPYGAP AGPLIVPYNL PLPGGVVPRM LITILGTVKP NANRIALDFQ RGNDVAFHFN PRFNENNRRV IVCNTKLDNN WGREERQSVF PFESGKPFKI QVLVEPDHFK VAVNDAHLLQ YNHRVK
Galectins are a new family of animal lectins which appear to exhibit a variety of biological functions and may in fact be a broad-spectrum biological response modifier. Galectin-3 is one of the more extensively studied member of this family and is a 30 kDa protein known by various other names including eBP (IgE binding protein), Mac-2, CBP-30 and L-29. Due to a C-terminal carbohydrate binding site, galectin-3 is capable of binding IgE and mammalian cell surfaces only when homodimerized or homooligomerized. MA1-940 has been shown to potentiate the binding of galectin-3 to IgG. Among its numerous proposed functions, galectin-3 may be a component of a cell-growth regulating system given its elevated expression and nuclear localization in proliferating cells. It has also been found to be a major non-integrin laminin-binding protein suggesting a role in cell adhesion. One of its more interesting proposed functions is as an inhibitor of apoptosis. Galectin-3 shares an NWGR motif with Bcl-2 which has been shown to be an important region in Bcl-2 for suppression of apoptosis. Galectin-3 has been shown to interact with Bcl-2 which may account for the ability of galectin-3 to suppress programmed cell death in anti-Fas (an apoptosis inducer) treated Jurkat cells transfected with galectin-3. In contrast to galectin-3, galectin-1 actually induces apoptosis when added to cultures of activated human T cells.
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Protein Aliases: 35 kDa lectin; advanced glycation end-product receptor 3; Carbohydrate-binding protein 35; CBP 35; Gal-3; Galactose-specific lectin 3; Galactoside-binding protein; GALBP; Galectin-3; GALIG; IgE-binding protein; L-31; Laminin-binding protein; Lectin L-29; lectin, galactoside-binding, soluble, 3; LGALS2; MAC-2; MAC-2 antigen
Gene Aliases: CBP35; GAL3; GALBP; GALIG; L31; LGALS2; LGALS3; MAC2
UniProt ID: (Human) P17931
Entrez Gene ID: (Human) 3958