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Galectin-6 is a member of the galectin family, characterized by its ability to bind specifically to beta-galactoside sugars. This protein is prominently expressed within the epithelial cells of the gastrointestinal tract in both embryonic and adult stages, appearing consistently from the stomach to the colon. Galectin-6 plays a significant role in the body's immune and microbial defense, acting as a novel anti-microbial peptide in the skin. It is known to be modulated by both the skin barrier and microbiome, emphasizing its involvement in maintaining skin homeostasis and protective functions. Beyond its antimicrobial roles, the galectin family, including galectin-6, is vital in regulating various cellular processes such as proliferation, adhesion, and migration, owing to its capacity to interact with specific glycans. This highlights galectin-6's broader implications in immune responses and inflammatory conditions, marking it as a potential focal point in studies relating to immunity and infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Gal-6; Galectin-6
Gene Aliases: galectin-6; Lgals6
UniProt ID: (Mouse) O54891
Entrez Gene ID: (Mouse) 16857
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