Invitrogen

Galectin 9 Polyclonal Antibody

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This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details

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Galectin 9 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of Galectin 9 in human rectum and skeletal muscle tissues using Galectin 9 Polyclonal Antibody (Product # PA5-61469). Corresponding LGALS9 RNA-seq data are presented for the same tissues.

Galectin 9 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of Galectin 9 in human lymph node using Galectin 9 Polyclonal Antibody (Product # PA5-61469) shows strong cytoplasmic positivity in non - germinal center cells.

Galectin 9 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of Galectin 9 in human rectum using Galectin 9 Polyclonal Antibody (Product # PA5-61469) shows strong cytoplasmic positivity in glandular cells.

Galectin 9 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of Galectin 9 in human colon using Galectin 9 Polyclonal Antibody (Product # PA5-61469) shows strong cytoplasmic positivity in glandular cells.

Galectin 9 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of Galectin 9 in human skeletal muscle using Galectin 9 Polyclonal Antibody (Product # PA5-61469) shows no positivity in myocytes.

Galectin 9 Antibody in Relative expression — Relative expression in different tissues in IHC: Detection of differential expression levels of Galectin 9 demonstrates antibody specificity. Immunohistochemical analysis of Galectin 9 using anti-Galectin 9 Polyclonal Antibody (Product # PA5-61469), shows significant staining of Galectin 9 in human rectum and shows minimal or weak staining in human skeletal muscle tissues. The relative expression levels of Galectin 9 within each tissue is shown using RNA-Seq. {RE}

Product Details

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Galectin 9

Conjugate

Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2641833

Product Specific Information

Immunogen sequence: RFDENAVVRN TQIDNSWGSE ERSLPRKMPF VRGQSFSVWI LCEAHCLKVA VDGQHLFEYY HRLRNLPTIN

Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 80%.

Target Information

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H and RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ecalectin; Gal-9; Gal9; Galectin-9; Galectin9; HOM HD 21; lectin, galactoside binding soluble 9; lectin, galactoside-binding, soluble, 9; Tumor antigen HOM-HD-21; urate transporter/channel protein

Gene Aliases: HUAT; LGALS9; LGALS9A

UniProt ID: (Human) O00182

Entrez Gene ID: (Human) 3965

Molecular Function: cell adhesion molecule signaling molecule

natural killer cell tolerance induction chemotaxis inflammatory response female pregnancy positive regulation of gene expression negative regulation of gene expression response to lipopolysaccharide regulation of interleukin-4 production regulation of interleukin-5 production negative regulation of chemokine production negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-4 production positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway p38MAPK cascade positive regulation of NF-kappaB import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of mast cell degranulation negative regulation of natural killer cell mediated cytotoxicity negative regulation of activated T cell proliferation positive regulation of viral entry into host cell positive regulation of interleukin-1 beta secretion positive regulation of NF-kappaB transcription factor activity maternal process involved in female pregnancy positive regulation of activated T cell autonomous cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade response to interleukin-1 cellular response to interferon-gamma positive regulation of transforming growth factor beta production positive regulation of monocyte chemotactic protein-1 production mature conventional dendritic cell differentiation cellular response to virus regulation of p38MAPK cascade positive regulation of interferon-gamma secretion positive regulation of tumor necrosis factor secretion positive regulation of interleukin-8 secretion positive regulation of dendritic cell chemotaxis negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of interleukin-13 secretion positive regulation of dendritic cell apoptotic process positive regulation of interleukin-6 secretion positive regulation of interleukin-10 secretion positive regulation of interleukin-12 secretion positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell positive regulation of dendritic cell differentiation positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Process(es)

signal transducer activity galactose binding enzyme binding carbohydrate binding disaccharide binding