This antibody is predicted to react with canine, mouse and rat based on sequence homology.
The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Actin-depolymerizing factor; ADF; ADFBrevin; AGEL; Brevin; DKFZp313L0718; Gelsolin; RP11-477J21.1
Gene Aliases: ADF; AGEL; GSN
UniProt ID: (Human) P06396
Entrez Gene ID: (Human) 2934
Molecular Function: non-motor actin binding protein