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Invitrogen
Gephyrin Polyclonal Antibody
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Product Details
PA5-149363
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human Gephyrin/GPHN, Ala2-Ser188
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Gephyrin is a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gephyrin; unnamed protein product
Gene Aliases: GEPH; GPH; GPHN; GPHRYN; HKPX1; KIAA1385; MOCODC
UniProt ID: (Human) Q9NQX3
Entrez Gene ID: (Human) 10243
nucleotide binding
catalytic activity
receptor binding
protein binding
ATP binding
nitrate reductase activity
transferase activity
protein binding, bridging
identical protein binding
molybdopterin cofactor binding
metal ion binding
binding, bridging
molybdopterin adenylyltransferase activity
molybdopterin molybdotransferase activity
Mo-molybdopterin cofactor biosynthetic process
synapse assembly
establishment of synaptic specificity at neuromuscular junction
response to metal ion
molybdopterin cofactor biosynthetic process
establishment of protein localization
synapse organization
synaptic transmission, GABAergic
glycine receptor clustering
protein localization to membrane
gamma-aminobutyric acid receptor clustering
neurotransmitter receptor localization to postsynaptic specialization membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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