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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues G(1) S S F L S P E H Q R V Q Q R K E S K K P P A K L P Q R(28) of human GHRL.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 1mg/ml BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-1046 detects recombinant human ghrelin. This antibody detect both the octanoylated and non-octanoylated forms of ghrelin.
PA1-1046 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~3 kDa protein representing recombinant human ghrelin.
The PA1-1046 immunogen is a synthetic peptide corresponding to residues G(1) S S F L S P E H Q R V Q Q R K E S K K P P A K L P Q R(28) of human GHRL.
Ghrelin was originally discovered as a preprohormone that stimulates the release of growth hormone from the anterior pituitary. Recent studies have shown that ghrelin, in concert with other hormones, helps to control both appetite and energy balance.
The synthesis of ghrelin takes place predominantly in epithelial cells of the stomach, although it is also produced in smaller quantities in the placenta, kidney, pituitary and hypothalamus. Ghrelin is produced as a preprohormone that is proteolytically cleaved to yield its active form, a 28-amino acid peptide. The further octanoylation modification of the ghrelin peptide is being implicated in the regulation of the hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Ghrelin; ghrelin, growth hormone secretagogue receptor ligand; ghrelin/obestatin preprohormone; growth hormone-releasing peptide; In2c-preproghrelin; motilin-related peptide; MTLRP; prepro-appetite regulatory hormone; preproghrelin
GHRL; MTLRP; UNQ524/PRO1066